Literature DB >> 12615692

Platelet activation and the formation of the platelet plug: deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpura.

Han-Mou Tsai1.   

Abstract

In the circulation, a plasma metalloprotease, ADAMTS13, cleaves von Willebrand factor (vWF) in a shear-dependent manner. This article reviews the role of this cleavage in regulating vWF-platelet interaction and proposes a scheme for understanding how a deficiency of ADAMTS13 results in the development of microthrombi in patients with thrombotic thrombocytopenic purpura.

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Year:  2003        PMID： 12615692     DOI： 10.1161/01.ATV.0000058401.34021.D4

Source DB:  PubMed          Journal:  Arterioscler Thromb Vasc Biol        ISSN： 1079-5642            Impact factor:   8.311


  9 in total

1.  Shear tango: dance of the ADAMTS13/VWF complex.

Authors:  Rens de Groot; David A Lane
Journal:  Blood       Date:  2008-09-01       Impact factor: 22.113

2.  Size regulation of von Willebrand factor-mediated platelet thrombi by ADAMTS13 in flowing blood.

Authors:  Roberta Donadelli; Jennifer N Orje; Cristina Capoferri; Giuseppe Remuzzi; Zaverio M Ruggeri
Journal:  Blood       Date:  2005-11-17       Impact factor: 22.113

3.  ADAMTS13 and von Willebrand factor interactions.

Authors:  Catherine B Zander; Wenjing Cao; X Long Zheng
Journal:  Curr Opin Hematol       Date:  2015-09       Impact factor: 3.284

Review 4.  Structure-function and regulation of ADAMTS-13 protease.

Authors:  X L Zheng
Journal:  J Thromb Haemost       Date:  2013-06       Impact factor: 5.824

5.  Formation and Resolution of Pial Microvascular Thrombosis in a Mouse Model of Thrombotic Thrombocytopenic Purpura.

Authors:  Reheman Adili; Michael Holinstat
Journal:  Arterioscler Thromb Vasc Biol       Date:  2019-07-25       Impact factor: 8.311

Review 6.  Hemostatic abnormalities in critically ill patients.

Authors:  Marcel Levi; Suthesh Sivapalaratnam
Journal:  Intern Emerg Med       Date:  2014-12-24       Impact factor: 3.397

7.  Acquired thrombotic thrombocytopenic purpura in children: a single institution experience.

Authors:  Somasundaram Jayabose; Theodore S Nowicki; Julie Dunbar; Oya Levendoglu-Tugal; Mehmet F Ozkaynak; Claudio Sandoval
Journal:  Indian J Pediatr       Date:  2012-12-21       Impact factor: 1.967

Review 8.  Coagulation abnormalities in critically ill patients.

Authors:  Marcel Levi; Steven M Opal
Journal:  Crit Care       Date:  2006       Impact factor: 9.097

9.  Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura.

Authors:  Louis Deforche; Claudia Tersteeg; Elien Roose; Aline Vandenbulcke; Nele Vandeputte; Inge Pareyn; Elien De Cock; Hanspeter Rottensteiner; Hans Deckmyn; Simon F De Meyer; Karen Vanhoorelbeke
Journal:  PLoS One       Date:  2016-08-01       Impact factor: 3.240
  9 in total

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