Literature DB >> 12615341

Trypanosoma cruzi genome encodes a pteridine reductase 2 protein.

Olga Senkovich1, Biswajit Pal, Norbert Schormann, Debasish Chattopadhyay.   

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Year:  2003        PMID： 12615341     DOI： 10.1016/s0166-6851(02)00309-2

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


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  4 in total

1.  Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.

Authors:  Alexis Nzila; Matthias Rottmann; Penchit Chitnumsub; Stevens M Kiara; Sumalee Kamchonwongpaisan; Cherdsak Maneeruttanarungroj; Supannee Taweechai; Bryan K S Yeung; Anne Goh; Suresh B Lakshminarayana; Bin Zou; Josephine Wong; Ngai Ling Ma; Margaret Weaver; Thomas H Keller; Veronique Dartois; Sergio Wittlin; Reto Brun; Yongyuth Yuthavong; Thierry T Diagana
Journal:  Antimicrob Agents Chemother       Date:  2010-03-29       Impact factor: 5.191

2.  Lipophilic antifolate trimetrexate is a potent inhibitor of Trypanosoma cruzi: prospect for chemotherapy of Chagas' disease.

Authors:  Olga Senkovich; Vandanajay Bhatia; Nisha Garg; Debasish Chattopadhyay
Journal:  Antimicrob Agents Chemother       Date:  2005-08       Impact factor: 5.191

3.  Crystallization and preliminary crystallographic studies of dihydrofolate reductase-thymidylate synthase from Trypanosoma cruzi, the Chagas disease pathogen.

Authors:  Penchit Chitnumsub; Jirundon Yuvaniyama; Thippayarat Chahomchuen; Tirayut Vilaivan; Yongyuth Yuthavong
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2009-10-30

4.  Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development.

Authors:  Antonio Cavazzuti; Giuseppe Paglietti; William N Hunter; Francisco Gamarro; Sandra Piras; Mario Loriga; Sergio Allecca; Paola Corona; Karen McLuskey; Lindsay Tulloch; Federica Gibellini; Stefania Ferrari; Maria Paola Costi
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-01       Impact factor: 11.205
  4 in total

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