Literature DB >> 12615315

Antiprotozoal activities of phospholipid analogues.

Simon L Croft1, Karin Seifert, Michael Duchêne.   

Abstract

The antiprotozoal activity of phospholipid analogues, originally developed as anti-cancer drugs, has been determined in the past decade. The most susceptible parasites are Leishmania spp. and Trypanosoma cruzi with activity also shown against Trypanosoma brucei spp., Entamoeba histolytica and Acanthamoeba spp. Miltefosine, an alkylphosphocholine, was registered for the oral treatment of visceral leishmaniasis (VL) in India in March 2002. This review will focus on the biological activities of phospholipid analogues. Biochemical and molecular targets and mechanism(s) of action have been studied extensively in tumor cells but have not been determined in protozoa. Copyright 2002 Elsevier Science B.V.

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Year:  2003        PMID： 12615315     DOI： 10.1016/s0166-6851(02)00283-9

Source DB:  PubMed          Journal:  Mol Biochem Parasitol        ISSN： 0166-6851            Impact factor:   1.759


  28 in total

1.  Hexadecylphosphocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis.

Authors:  Fred Widmer; Lesley C Wright; Daniel Obando; Rosemary Handke; Ranjini Ganendren; David H Ellis; Tania C Sorrell
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

2.  Therapeutic switching in leishmania chemotherapy: a distinct approach towards unsatisfied treatment needs.

Authors:  Nishi Shakya; Preeti Bajpai; Suman Gupta
Journal:  J Parasit Dis       Date:  2011-05-20

3.  Miltefosine increases lipid and protein dynamics in Leishmania amazonensis membranes at concentrations similar to those needed for cytotoxicity activity.

Authors:  Rodrigo Alves Moreira; Sebastião Antonio Mendanha; Kelly Souza Fernandes; Grazzielle Guimaraes Matos; Lais Alonso; Miriam Leandro Dorta; Antonio Alonso
Journal:  Antimicrob Agents Chemother       Date:  2014-03-10       Impact factor: 5.191

4.  Comparative study on the short term efficacy and adverse effects of miltefosine and meglumine antimoniate in dogs with natural leishmaniosis.

Authors:  Marta Mateo; Laurence Maynard; Claudia Vischer; Paolo Bianciardi; Guadalupe Miró
Journal:  Parasitol Res       Date:  2009-02-24       Impact factor: 2.289

5.  Antimicrobial activity of euplotin C, the sesquiterpene taxonomic marker from the marine ciliate Euplotes crassus.

Authors:  Dianella Savoia; Claudio Avanzini; Tiziano Allice; Emanuela Callone; Graziano Guella; Fernando Dini
Journal:  Antimicrob Agents Chemother       Date:  2004-10       Impact factor: 5.191

6.  A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation.

Authors:  Gabriella Pessi; Guillermo Kociubinski; Choukri Ben Mamoun
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-08       Impact factor: 11.205

7.  Pharmacotherapeutic options for visceral leishmaniasis-current scenario.

Authors:  Krishna Pandey; Prabhat Kumar Sinha; Vidyanand Ravi Das; Sanjiva Bimal; Shubhankar K Singh; Pradeep Das
Journal:  Clin Med Pathol       Date:  2009-01-23

8.  Miltefosine (hexadecylphosphocholine) inhibits cytochrome c oxidase in Leishmania donovani promastigotes.

Authors:  Juan Román Luque-Ortega; Luis Rivas
Journal:  Antimicrob Agents Chemother       Date:  2007-02-05       Impact factor: 5.191

9.  Possible mechanism of miltefosine-mediated death of Leishmania donovani.

Authors:  Navin K Verma; Chinmoy S Dey
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

10.  Characterization of Leishmania major phosphatidylethanolamine methyltransferases LmjPEM1 and LmjPEM2 and their inhibition by choline analogs.

Authors:  Stergios S Bibis; Kelly Dahlstrom; Tongtong Zhu; Rachel Zufferey
Journal:  Mol Biochem Parasitol       Date:  2014-08-29       Impact factor: 1.759
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