Literature DB >> 12615247

Identification of photoproducts of folic acid and its degradation pathways in aqueous solution.

M Jamil Akhtar1, M Ataullah Khan, Iqbal Ahmad.   

Abstract

The UV irradiated aqueous solutions of folic acid at pH 2-10 degrade to give pterin-6-carboxylic acid and p-aminobenzoyl-L-glutamic acid under aerobic conditions. These photoproducts have been identified by TLC, HPLC and Spectrophotometric techniques. A reaction scheme for the photodegradation pathways of folic acid leading to the formation of the photoproducts in acid and alkaline media has been proposed which involves the participation of an enamine intermediate.

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Year:  2003        PMID: 12615247     DOI: 10.1016/s0731-7085(02)00724-0

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN: 0731-7085            Impact factor:   3.935


  4 in total

1.  Ethyl cellulose microcapsules for protecting and controlled release of folic acid.

Authors:  Satit Prasertmanakit; Nalena Praphairaksit; Worawadee Chiangthong; Nongnuj Muangsin
Journal:  AAPS PharmSciTech       Date:  2009-09-10       Impact factor: 3.246

2.  Degradation of 5-methyltetrahydrofolate in model and egg yolk systems and strategies for its stabilization.

Authors:  Yan Yang; Junhua Li; Luping Gu; Cuihua Chang; Yujie Su; Yin Liu; Yanjun Yang; Shijian Dong
Journal:  J Food Sci Technol       Date:  2021-02-03       Impact factor: 3.117

3.  Optical properties of folic acid in phosphate buffer solutions: the influence of pH and UV irradiation on the UV-VIS absorption spectra and photoluminescence.

Authors:  Mihaela Baibarac; Ion Smaranda; Andreea Nila; Constantin Serbschi
Journal:  Sci Rep       Date:  2019-10-03       Impact factor: 4.379

4.  A Comprehensive Approach to Compatibility Testing Using Chromatographic, Thermal and Spectroscopic Techniques: Evaluation of Potential for a Monolayer Fixed-Dose Combination of 6-Mercaptopurine and Folic Acid.

Authors:  Edvin Brusač; Mario-Livio Jeličić; Matija Cvetnić; Daniela Amidžić Klarić; Biljana Nigović; Ana Mornar
Journal:  Pharmaceuticals (Basel)       Date:  2021-03-17
  4 in total

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