| Literature DB >> 12615065 |
Mitsushi Shimada1, Yukari Date, Muhtashan S Mondal, Koji Toshinai, Takuya Shimbara, Kyoko Fukunaga, Noboru Murakami, Mikiya Miyazato, Kenji Kangawa, Hironobu Yoshimatsu, Hisayuki Matsuo, Masamitsu Nakazato.
Abstract
Ghrelin is an acylated peptide that stimulates food intake and the secretion of growth hormone. While ghrelin is predominantly synthesized in a subset of endocrine cells in the oxyntic gland of the human and rat stomach, the mechanism regulating ghrelin secretion remains unknown. Somatostatin, a peptide produced in the gastric oxyntic mucosa, is known to suppress secretion of several gastrointestinal peptides in a paracrine fashion. By double immunohistochemistry, we demonstrated that somatostatin-immunoreactive cells contact ghrelin-immunoreactive cells. A single intravenous injection of somatostatin reduced the systemic plasma concentration of ghrelin in rats. Continuous infusion of somatostatin into the gastric artery of the vascularly perfused rat stomach suppressed ghrelin secretion in both dose- and time-dependent manner. These findings indicate that ghrelin secretion from the stomach is regulated by gastric somatostatin.Entities:
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Year: 2003 PMID： 12615065 DOI： 10.1016/s0006-291x(03)00178-5
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575