Literature DB >> 12614889

Synthesis and bioactivity of 4,10-dimethyl-pyridino[2,3-h]quinolin-2(1H)-one-9-carboxylic acid and its esters.

Qian Zhang1, Ying Chen, Yun Qing Zheng, Peng Xia, Yi Xia, Zheng Yu Yang, Kenneth F Bastow, Susan L Morris-Natschke, Kuo Hsiung Lee.   

Abstract

4,10-Dimethyl-pyridino[2,3-h]quinolin-2(1H)-one-9-carboxylic acid (1) was synthesized by a new approach via the key intermediate 7-[1-aza-2-(dimethylamino)vinyl]-4-methylquinolin-2(1H)-one (4). Compound 1 and its esters were evaluated in cytotoxicity and anti-HIV assays. The 9-carboxyl (1s)-endo-(-)-borneol ester (9) showed marginal cytotoxic activity in CAK1-1, HOS, KB, and HCT-8 cells.

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Year:  2003        PMID： 12614889     DOI： 10.1016/s0968-0896(02)00526-6

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  3 in total

1.  Design, synthesis, graph theoretical analysis and molecular modelling studies of novel substituted quinoline analogues as promising anti-breast cancer agents.

Authors:  Prachita Gauns Dessai; Shivani Prabhu Dessai; Renuka Dabholkar; Padmashree Pednekar; Sahili Naik; Shivlingrao Mamledesai; Murugananthan Gopal; Parasuraman Pavadai; Banoth Karan Kumar; Sankaranarayanan Murugesan; Sachin Chandavarkar; Panneerselvam Theivendren; Kunjiappan Selvaraj
Journal:  Mol Divers       Date:  2022-08-17       Impact factor: 3.364

2.  Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-carboxamidocyclazocine.

Authors:  Mark P Wentland; Xufeng Sun; Dana J Cohen; Jean M Bidlack
Journal:  Bioorg Med Chem       Date:  2008-03-30       Impact factor: 3.641

3.  Synthesis, characterization, and antimicrobial evaluation of carbostyril derivatives of 1H-pyrazole.

Authors:  Nilesh J Thumar; Manish P Patel
Journal:  Saudi Pharm J       Date:  2011-02-03       Impact factor: 4.330
  3 in total

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