Literature DB >> 12612453

Inhibitory effect of norditerpenes on LPS-induced TNF-alpha production from the Okinawan soft coral, Sinularia sp.

Hiroko Takaki1, Ryoji Koganemaru, You Iwakawa, Ryuichi Higuchi, Tomofumi Miyamoto.   

Abstract

An ethanol (EtOH) extract of the soft coral (Sinularia sp.), collected in Okinawa, demonstrated a potent inhibitory effect on lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF-alpha) production by murine macrophage-like cells (RAW264.7). The activity-guided purification of the EtOH extract resulted in the isolation of two norditerpenes, norcembrenolide (1) and sinuleptolide (2). These structures were identified from the spectroscopic data. Norcembrenolide (1) and sinuleptolide (2) inhibited TNF-alpha production in a dose-dependent manner, and showed a more potent effect than prednisolone at the concentration of 33 microg/ml. They also exhibited an inhibitory effect on nitric oxide (NO) production not influenced by cytotoxicity.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12612453     DOI： 10.1248/bpb.26.380

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN： 0918-6158            Impact factor:   2.233


  10 in total

1.  Total synthesis of norcembrenolide B and scabrolide D.

Authors:  Alec Saitman; Pauline Rulliere; Steven D E Sullivan; Emmanuel A Theodorakis
Journal:  Org Lett       Date:  2011-10-05       Impact factor: 6.005

2.  5-Episinuleptolide Decreases the Expression of the Extracellular Matrix in Early Biofilm Formation of Multi-Drug Resistant Acinetobacter baumannii.

Authors:  Sung-Pin Tseng; Wei-Chun Hung; Chiung-Yao Huang; Yin-Shiou Lin; Min-Yu Chan; Po-Liang Lu; Lin Lin; Jyh-Horng Sheu
Journal:  Mar Drugs       Date:  2016-07-29       Impact factor: 5.118

3.  Diastereoselective Synthesis of Highly Substituted Tetrahydrofurans by Pd-Catalyzed Tandem Oxidative Cyclization-Redox Relay Reactions Controlled by Intramolecular Hydrogen Bonding.

Authors:  Joshua L Brooks; Liping Xu; Olaf Wiest; Derek S Tan
Journal:  J Org Chem       Date:  2016-12-22       Impact factor: 4.354

4.  Reactive oxygen species mediate soft corals-derived sinuleptolide-induced antiproliferation and DNA damage in oral cancer cells.

Authors:  Yung-Ting Chang; Chiung-Yao Huang; Jen-Yang Tang; Chih-Chuang Liaw; Ruei-Nian Li; Jing-Ru Liu; Jyh-Horng Sheu; Hsueh-Wei Chang
Journal:  Onco Targets Ther       Date:  2017-07-04       Impact factor: 4.147

5.  5-epi-Sinuleptolide from Soft Corals of the Genus Sinularia Exerts Cytotoxic Effects on Pancreatic Cancer Cell Lines via the Inhibition of JAK2/STAT3, AKT, and ERK Activity.

Authors:  Wan-Chi Tsai; Wen-Hung Wang; Bo-Cian Huang; Chiung-Yao Huang; Jyh-Horng Sheu
Journal:  Molecules       Date:  2021-11-17       Impact factor: 4.411

6.  Polyoxygenated sterols from the South China Sea soft coral Sinularia sp.

Authors:  Rui Li; Chang-Lun Shao; Xin Qi; Xiu-Bao Li; Jing Li; Ling-Ling Sun; Chang-Yun Wang
Journal:  Mar Drugs       Date:  2012-06-26       Impact factor: 6.085

7.  Secosteroids and norcembranoids from the soft coral Sinularia nanolobata.

Authors:  Yen-Ju Tseng; Shang-Kwei Wang; Chang-Yih Duh
Journal:  Mar Drugs       Date:  2013-08-27       Impact factor: 5.118

8.  Bioactive cembrane derivatives from the Indian Ocean soft coral, Sinularia kavarattiensis.

Authors:  Katja-Emilia Lillsunde; Carmen Festa; Harshada Adel; Simona De Marino; Valter Lombardi; Supriya Tilvi; Dorota A Nawrot; Angela Zampella; Lisette D'Souza; Maria Valeria D'Auria; Päivi Tammela
Journal:  Mar Drugs       Date:  2014-07-03       Impact factor: 5.118

9.  Discovering the Biological Target of 5-epi-Sinuleptolide Using a Combination of Proteomic Approaches.

Authors:  Elva Morretta; Roberta Esposito; Carmen Festa; Raffaele Riccio; Agostino Casapullo; Maria Chiara Monti
Journal:  Mar Drugs       Date:  2017-10-13       Impact factor: 5.118

10.  Sandensolide Induces Oxidative Stress-Mediated Apoptosis in Oral Cancer Cells and in Zebrafish Xenograft Model.

Authors:  Chung-I Yu; Chung-Yi Chen; Wangta Liu; Po-Chih Chang; Chiung-Wei Huang; Kuang-Fen Han; In-Pin Lin; Mei-Ying Lin; Chien-Hsing Lee
Journal:  Mar Drugs       Date:  2018-10-16       Impact factor: 5.118
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.