Literature DB >> 12611163

[Therapy of postresuscitation behavioral disorders with mexidol and kyotorphin].

N A Gorenkova, I V Nazarenko, I V Samorukova, M Sh Avrushchenko, A V Volkov.   

Abstract

A complex of behavioral tests revealed diminished anxiety, increased locomotor and exploratory activities, and changes in different learning tests in resuscitated animals. Mexidol alone and in combination with kyotorphin exhibited antistressogenic and nootropic activities, and led to a compensation of ischemic lesions in rats. It can be stated that a the injection of mexidol in combination with kyotorphin yielded better results due to its neuroprotective effect in the CA1 and CA4 fields of the hippocampus.

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Year:  2002        PMID: 12611163

Source DB:  PubMed          Journal:  Anesteziol Reanimatol        ISSN: 0201-7563


  1 in total

1.  Neuropeptide Kyotorphin (Tyrosyl-Arginine) has Decreased Levels in the Cerebro-Spinal Fluid of Alzheimer's Disease Patients: Potential Diagnostic and Pharmacological Implications.

Authors:  Sara Matos Santos; Laura Garcia-Nimo; Sónia Sá Santos; Isaura Tavares; José A Cocho; Miguel A R B Castanho
Journal:  Front Aging Neurosci       Date:  2013-10-30       Impact factor: 5.750

  1 in total

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