OBJECTIVE: To evaluate the efficacy of eutectic lidocaine/prilocaine cream (EMLA) in reducing the pain associated with steroid joint injection in children with juvenile arthritis. METHODS: A randomized, double blind, placebo controlled parallel group trial. Thirty-one children (ages 8-18 yrs) scheduled forsteroid injection into a knee were randomized into groups having either 2.5 g lidocaine/prilocaine cream or placebo cream applied to the injection site 60-90 min before the procedure. Patients assessed the pain associated with initial needle insertion and subsequent steroid injection using a 10 cm visual analog scale. RESULTS: No significant difference was found in the pain reported after needle insertion or steroid injection between the lidocaine/prilocaine cream group (n = 17) and the placebo group (n = 14). There was a trend toward an association of lower median scores with the pain of steroid injection in the lidocaine/prilocaine group (6 mm) compared with the placebo group (22 mm). CONCLUSION: Application of 2.5 g lidocaine/prilocaine cream for 60-90 min had no statistically significant analgesic effect on pain associated with injections of steroids into the knees of children with juvenile arthritis.
RCT Entities:
OBJECTIVE: To evaluate the efficacy of eutectic lidocaine/prilocaine cream (EMLA) in reducing the pain associated with steroid joint injection in children with juvenile arthritis. METHODS: A randomized, double blind, placebo controlled parallel group trial. Thirty-one children (ages 8-18 yrs) scheduled for steroid injection into a knee were randomized into groups having either 2.5 g lidocaine/prilocaine cream or placebo cream applied to the injection site 60-90 min before the procedure. Patients assessed the pain associated with initial needle insertion and subsequent steroid injection using a 10 cm visual analog scale. RESULTS: No significant difference was found in the pain reported after needle insertion or steroid injection between the lidocaine/prilocaine cream group (n = 17) and the placebo group (n = 14). There was a trend toward an association of lower median scores with the pain of steroid injection in the lidocaine/prilocaine group (6 mm) compared with the placebo group (22 mm). CONCLUSION: Application of 2.5 g lidocaine/prilocaine cream for 60-90 min had no statistically significant analgesic effect on pain associated with injections of steroids into the knees of children with juvenile arthritis.
Authors: H T Draeger; J M Twining; C R Johnson; S C Kettwich; L G Kettwich; A D Bankhurst Journal: Ann Rheum Dis Date: 2005-12-08 Impact factor: 19.103
Authors: Kye S Park; Andres Peisajovich; Adrian A Michael; Wilmer L Sibbitt; Arthur D Bankhurst Journal: Rheumatol Int Date: 2008-11-27 Impact factor: 2.631
Authors: Anita Kovács; Nikolett Kis; Mária Budai-Szűcs; Attila Gácsi; Erzsébet Csányi; Ildikó Csóka; Szilvia Berkó Journal: Drug Des Devel Ther Date: 2020-11-18 Impact factor: 4.162
Authors: Jennifer E Weiss; Kathleen A Haines; Elizabeth C Chalom; Suzanne C Li; Gary A Walco; Themba L Nyirenda; Barbara Edelheit; Yukiko Kimura Journal: Pediatr Rheumatol Online J Date: 2015-08-27 Impact factor: 3.054