| Literature DB >> 12610309 |
Anne F Simon1, Cindy Shih, Antha Mack, Seymour Benzer.
Abstract
Ecdysone, the major steroid hormone of Drosophila melanogaster, is known for its role in development and reproduction. Flies that are heterozygous for mutations of the ecdysone receptor exhibit increases in life-span and resistance to various stresses, with no apparent deficit in fertility or activity. A mutant involved in the biosynthesis of ecdysone displays similar effects, which are suppressed by feeding ecdysone to the flies. These observations demonstrate the importance of the ecdysone hormonal pathway, a new player in regulating longevity.Entities:
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Year: 2003 PMID： 12610309 DOI： 10.1126/science.1080539
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728