Literature DB >> 12610157

Epstein-Barr virus (EBV) nuclear antigen 1 colocalizes with cellular replication foci in the absence of EBV plasmids.

Sayuri Ito1, Kazuo Yanagi.   

Abstract

Epstein-Barr virus (EBV) EBNA-1 is the only EBV-encoded protein that is essential for the once-per-cell-cycle replication and maintenance of EBV plasmids in latently infected cells. EBNA-1 binds to the oriP region of latent EBV plasmids and cellular metaphase chromosomes. In the absence of oriP-containing plasmids, EBNA-1 was highly colocalized with cellular DNA replication foci that were identified by immunostaining S-phase cells for proliferating cell nuclear antigen and replication protein A (RP-A) in combination with DNA short pulse-labeling. For the association of EBNA-1 with the cellular replication focus areas, the EBNA-1 regions of amino acids (aa) 8 to 94 and/or aa 315 to 410, but not the RP-A-interacting carboxy-terminal region, were necessary. These results suggest a new aspect of latent virus-cell interactions.

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Year:  2003        PMID： 12610157      PMCID： PMC149516          DOI： 10.1128/jvi.77.6.3824-3831.2003

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  44 in total

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Journal:  EMBO Rep       Date:  2000-08       Impact factor: 8.807

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  5 in total

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Authors:  Ryo Kitamura; Toshihiro Sekimoto; Sayuri Ito; Shizuko Harada; Hideo Yamagata; Hisao Masai; Yoshihiro Yoneda; Kazuo Yanagi
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4.  The BAH domain facilitates the ability of human Orc1 protein to activate replication origins in vivo.

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  5 in total

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