OBJECTIVE: To investigate whether quantity or quality of dietary fat predicts coronary heart disease (CHD) events in middle-aged type 2 diabetic subjects. RESEARCH DESIGN AND METHODS: The dietary habits of 366 type 2 diabetic men and 295 women, aged 45-64 years and free from CHD, were assessed with a 53-item food frequency questionnaire. They were followed up for 7 years. RESULTS: Men in the highest tertile of the polyunsaturated/saturated fat (P/S) ratio (>0.28) had a significantly lower risk for CHD death than men in the two lowest tertiles (5.0 vs. 14.2%, P = 0.009). The risk for all CHD events was 14.2 vs. 23.2%, respectively (P = 0.044). P/S ratio did not predict CHD events in women. In Cox multiple regression analyses taking into account other cardiovascular risk factors, the highest P/S ratio tertile was associated with the lowest rate of CHD death in men (P = 0.048). CONCLUSIONS: Low P/S ratio in men predicted future CHD events in type 2 diabetic subjects independently of conventional CHD risk factors.
OBJECTIVE: To investigate whether quantity or quality of dietary fat predicts coronary heart disease (CHD) events in middle-aged type 2 diabetic subjects. RESEARCH DESIGN AND METHODS: The dietary habits of 366 type 2 diabeticmen and 295 women, aged 45-64 years and free from CHD, were assessed with a 53-item food frequency questionnaire. They were followed up for 7 years. RESULTS:Men in the highest tertile of the polyunsaturated/saturated fat (P/S) ratio (>0.28) had a significantly lower risk for CHD death than men in the two lowest tertiles (5.0 vs. 14.2%, P = 0.009). The risk for all CHD events was 14.2 vs. 23.2%, respectively (P = 0.044). P/S ratio did not predict CHD events in women. In Cox multiple regression analyses taking into account other cardiovascular risk factors, the highest P/S ratio tertile was associated with the lowest rate of CHD death in men (P = 0.048). CONCLUSIONS: Low P/S ratio in men predicted future CHD events in type 2 diabetic subjects independently of conventional CHD risk factors.
Authors: Diewertje Sluik; Heiner Boeing; Kuanrong Li; Rudolf Kaaks; Nina Føns Johnsen; Anne Tjønneland; Larraitz Arriola; Aurelio Barricarte; Giovanna Masala; Sara Grioni; Rosario Tumino; Fulvio Ricceri; Amalia Mattiello; Annemieke M W Spijkerman; Daphne L van der A; Ivonne Sluijs; Paul W Franks; Peter M Nilsson; Marju Orho-Melander; Eva Fhärm; Olov Rolandsson; Elio Riboli; Dora Romaguera; Elisabete Weiderpass; Emilio Sánchez-Cantalejo; Ute Nöthlings Journal: Diabetologia Date: 2013-10-17 Impact factor: 10.122
Authors: Carlos Jiménez-Cortegana; Pedro Iglesias; Josep Ribalta; Teresa Vilariño-García; Laura Montañez; Francisco Arrieta; Manuel Aguilar; Santiago Durán; Juan C Obaya; Antonio Becerra; Juan Pedro-Botet; Víctor Sánchez-Margalet Journal: Nutrients Date: 2021-11-19 Impact factor: 5.717