| Literature DB >> 12609230 |
Eroboghene E Ubogu1, Stephen M Sagar, Alan J Lerner, Brian N Maddux, José I Suarez, Mary Ann Werz.
Abstract
A 44-year-old man with treated neurosyphilis presented with subclinical status epilepticus (SE) refractory to intravenous high-dose lorazepam, phenytoin, and valproic acid over 4 days. Ketamine infusion was instituted after low-dose propofol sedation with gradual control of electrographic seizures over 72h. Reevaluation 3 months later revealed diffuse cerebellar and worsened cerebral atrophy, consistent with animal models of N-methyl-D-aspartate antagonist-mediated neurotoxicity. Animal studies of prolonged ketamine therapy are required before widespread human use in SE.Entities:
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Year: 2003 PMID： 12609230 DOI： 10.1016/s1525-5050(02)00643-1
Source DB: PubMed Journal: Epilepsy Behav ISSN： 1525-5050 Impact factor: 2.937