Parkinsonism and Epilepsy: Case Report and Reappraisal of an Old Question.

Since Yakovlev's contribution in 1928, very few cases with parkinsonism and epilepsy have been reported in the literature. While antagonism has been claimed between the two conditions, little is hypothesized about the pathophysiological mechanisms involved. We report the case of a patient with both temporal lobe epilepsy and Parkinson's disease, who presented with a dramatic decrease in seizure frequency when the parkinsonian signs developed and disappearance of motor fluctuations following recurrence of seizures. On the basis of recent knowledge regarding both pathologies we propose new insights into this old question.