Experimental barbiturate intoxication: treatment by partial cardiopulmonary bypass and hemodialysis.

1. The results of a series of experiments in which anesthetized mongrel dogs were instrumented and preparations for closed-chest partial cardiopulmonary bypass with membrane oxygenation and hemodialysis were made, following which "fatal" barbiturate intoxication was produced by the intravenous route has been presented. 2. Of nine animals, three (33 l/3%) could be removed from cardiopulmonary bypass although postoperative cardiovascular dynamics remained abnormal. 3. The clinical implications of this study in patients with cardiac depression in spite of hemodialysis for barbiturate intoxication seemed promising.