Literature DB >> 1260769

Antileukemic effects of pseudoisocytidine, a new synthetic pyrimidine C-nucleoside.

J H Burchenal, K Ciovacco, K Kalaher, T O'Toole, R Kiefner, M D Dowling, C K Chu, K A Watanabe, I Wempen, J J Fox.   

Abstract

Pseudoisocytidine, a new synthetic pyrimidine C-nucleoside, which might be considered a more stable analog of 5-azacytidine, is active in vitro and in vivo, i.p. and p.o., against various 1-beta-D-arabinofuranosylcytosine-resistant lines of mouse leukemia. This antileukemic activity is blocked by cytidine but not by deoxycytidine or thymidine.

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Year:  1976        PMID： 1260769

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  6 in total

1.  Theoretical study of the intermolecular H-bonding and intermolecular proton transfer between isocytosine tautomeric forms and R,S-lactic acid.

Authors:  Vassil B Delchev; Hans Mikosch
Journal:  J Mol Model       Date:  2006-05-19       Impact factor: 1.810

2.  Delineation of the molecular mechanisms of nucleoside recognition by cytidine deaminase through virtual screening.

Authors:  Stefano Costanzi; Santiago Vilar; Daniela Micozzi; Francesco M Carpi; Giulio Ferino; Alberto Vita; Silvia Vincenzetti
Journal:  ChemMedChem       Date:  2011-05-19       Impact factor: 3.466

Review 3.  DNA methylation as a target for drug design.

Authors:  C M Bender; J M Zingg; P A Jones
Journal:  Pharm Res       Date:  1998-02       Impact factor: 4.200

4.  Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position.

Authors:  Erin E Doherty; Xander E Wilcox; Lenka van Sint Fiet; Cherie Kemmel; Janne J Turunen; Bart Klein; Dean J Tantillo; Andrew J Fisher; Peter A Beal
Journal:  J Am Chem Soc       Date:  2021-05-03       Impact factor: 15.419

5.  Synthetic Approaches for the Preparation of Phosphoramidate Prodrugs of 2'-Deoxypseudoisocytidine.

Authors:  Michaela Serpi; Roberto De Biasi; Fabrizio Pertusati; Magdalena Slusarczyk; Christopher McGuigan
Journal:  ChemistryOpen       Date:  2017-05-05       Impact factor: 2.911

6.  Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides.

Authors:  Jagadeeshwar R Rao; Raymond F Schinazi; Chung K Chu
Journal:  Bioorg Med Chem       Date:  2006-10-25       Impact factor: 3.641
  6 in total

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