Literature DB >> 12605555

deCODE genetics, Inc.

Hakon Hakonarson1, Jeffrey R Gulcher, Kari Stefansson.   

Abstract

deCODE genetics, Inc. has compiled the world's most comprehensive collection of population data on genealogy, genotypes and phenotypes. This combination of resources provides an effective system for identifying key genes linked to common diseases and to the regulation of drug response. deCODE has successfully mapped genes in over 25 common complex diseases and isolated genes in eight of these. The methodology used to map these genes is based upon the company's genealogical database of the Icelandic population, which enables deCODE scientists to efficiently conduct population- and genome-wide linkage studies to identify key genetic factors involved in phenotypes ranging from diseases to drug response. In its growing pharmacogenomics program, deCODE has combined this linkage approach with high-throughput expression profiling to develop accurate tests that can predict individual responsiveness to virtually any drug of interest. deCODE is applying its unrivaled discovery capabilities to bring to market new drugs, DNA-based diagnostic products and pharmacogenomic tests. The company believes that such tests will play a crucial role in delivering personalized medicine - contributing to the development of more effective means of diagnosing and treating disease by matching each patient with the most suitable drug.

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Year:  2003        PMID: 12605555     DOI: 10.1517/phgs.4.2.209.22627

Source DB:  PubMed          Journal:  Pharmacogenomics        ISSN: 1462-2416            Impact factor:   2.533


  13 in total

1.  Gene-environment interaction with smoking for increased non-muscle-invasive bladder cancer tumor size.

Authors:  Nadezda Lipunova; Anke Wesselius; Kar K Cheng; Frederik-Jan van Schooten; Richard T Bryan; Jean-Baptiste Cazier; Maurice P Zeegers
Journal:  Transl Androl Urol       Date:  2020-06

2.  Neuregulin-1 genotypes and eye movements in schizophrenia.

Authors:  H Magnus Haraldsson; Ulrich Ettinger; Brynja B Magnusdottir; Andres Ingason; Samuel B Hutton; Thordur Sigmundsson; Engilbert Sigurdsson; Hannes Petursson
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2009-07-03       Impact factor: 5.270

3.  PINK1 mutations and parkinsonism.

Authors:  L Ishihara-Paul; M M Hulihan; J Kachergus; R Upmanyu; L Warren; R Amouri; R Elango; R K Prinjha; A Soto; M Kefi; M Zouari; S B Sassi; S B Yahmed; G El Euch-Fayeche; P M Matthews; L T Middleton; R A Gibson; F Hentati; M J Farrer
Journal:  Neurology       Date:  2008-08-06       Impact factor: 9.910

Review 4.  Genomic and Phenomic Research in the 21st Century.

Authors:  Scott Hebbring
Journal:  Trends Genet       Date:  2018-10-17       Impact factor: 11.639

5.  Translation research: from accurate diagnosis to appropriate treatment.

Authors:  Craig P Webb; Harvey I Pass
Journal:  J Transl Med       Date:  2004-10-21       Impact factor: 5.531

6.  A generic solution for web-based management of pseudonymized data.

Authors:  Ronald Lautenschläger; Florian Kohlmayer; Fabian Prasser; Klaus A Kuhn
Journal:  BMC Med Inform Decis Mak       Date:  2015-11-30       Impact factor: 2.796

7.  Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization.

Authors:  David M Evans; Gunn-Helen Moen; Liang-Dar Hwang; Debbie A Lawlor; Nicole M Warrington
Journal:  Int J Epidemiol       Date:  2019-06-01       Impact factor: 7.196

8.  Pseudonymization for research data collection: is the juice worth the squeeze?

Authors:  Florian Kohlmayer; Ronald Lautenschläger; Fabian Prasser
Journal:  BMC Med Inform Decis Mak       Date:  2019-09-04       Impact factor: 2.796

9.  Public health in the genomic era: will Public Health Genomics contribute to major changes in the prevention of common diseases?

Authors:  Evy Cleeren; Johan Van der Heyden; Angela Brand; Herman Van Oyen
Journal:  Arch Public Health       Date:  2011-12-05

10.  What's more general than a whole population?

Authors:  Neal Alexander
Journal:  Emerg Themes Epidemiol       Date:  2015-08-25
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