Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Haplotype analysis in population genetics and association studies.

Literature DB >> 12605551

Haplotype analysis in population genetics and association studies.

Hongyu Zhao¹, Ruth Pfeiffer, Mitchell H Gail.

Abstract

Several studies of haplotype structures in the human genome in various populations have been published recently. Such knowledge may provide valuable information on human evolutionary history and lead to the development of more efficient strategies to identify genetic variants that increase susceptibility to human diseases. In this review, we summarize the current understanding of haplotype structure, diversity, and distribution in the human genome, with a focus on statistical issues in using haplotypes for studies of population genetics and evolutionary history, as well as to identify genetic variants underlying complex human traits.

Entities: Species

Mesh：

Year: 2003 PMID： 12605551 DOI： 10.1517/phgs.4.2.171.22636

Source DB: PubMed Journal: Pharmacogenomics ISSN： 1462-2416 Impact factor: 2.533

Keyword Cloud
Cited

52 in total

1. Testing computational prediction of missense mutation phenotypes: functional characterization of 204 mutations of human cystathionine beta synthase.

Authors: Qiong Wei; Liqun Wang; Qiang Wang; Warren D Kruger; Roland L Dunbrack
Journal: Proteins Date: 2010-07

2. Practical Consideration of Genotype Imputation: Sample Size, Window Size, Reference Choice, and Untyped Rate.

Authors: Boshao Zhang; Degui Zhi; Kui Zhang; Guimin Gao; Nita N Limdi; Nianjun Liu
Journal: Stat Interface Date: 2011 Impact factor: 0.582

3. The impact of using related individuals for haplotype reconstruction in population studies.

Authors: Michael T Schouten; Christopher K I Williams; Chris S Haley
Journal: Genetics Date: 2005-06-08 Impact factor: 4.562

4. Multilocus association mapping using variable-length Markov chains.

Authors: Sharon R Browning
Journal: Am J Hum Genet Date: 2006-04-07 Impact factor: 11.025

5. Association mapping via regularized regression analysis of single-nucleotide-polymorphism haplotypes in variable-sized sliding windows.

Authors: Yi Li; Wing-Kin Sung; Jian Jun Liu
Journal: Am J Hum Genet Date: 2007-02-19 Impact factor: 11.025

10. A survey of haplotype variants at several disease candidate genes: the importance of rare variants for complex diseases.

Authors: P-Y Liu; Y-Y Zhang; Y Lu; J-R Long; H Shen; Lan-J Zhao; F-H Xu; P Xiao; D-H Xiong; Y-J Liu; R R Recker; H-W Deng
Journal: J Med Genet Date: 2005-03 Impact factor: 6.318

Haplotype analysis in population genetics and association studies.

1. Testing computational prediction of missense mutation phenotypes: functional characterization of 204 mutations of human cystathionine beta synthase.

2. Practical Consideration of Genotype Imputation: Sample Size, Window Size, Reference Choice, and Untyped Rate.

3. The impact of using related individuals for haplotype reconstruction in population studies.

4. Multilocus association mapping using variable-length Markov chains.

5. Association mapping via regularized regression analysis of single-nucleotide-polymorphism haplotypes in variable-sized sliding windows.

6. Powerful multi-marker association tests: unifying genomic distance-based regression and logistic regression.

7. Association mapping by generalized linear regression with density-based haplotype clustering.

8. Asymptotic tests of association with multiple SNPs in linkage disequilibrium.

9. Population genetics and comparative genetics of CLDN1, a gene involved in hepatitis C virus entry.

10. A survey of haplotype variants at several disease candidate genes: the importance of rare variants for complex diseases.