Literature DB >> 12605342

Leptin resistance - or why leptin fails to work in obesity.

K El-Haschimi1, H Lehnert.   

Abstract

In experimental models of obesity high serum concentrations of leptin without subsequent inhibition of food intake indicate a resistance to the physiological effects of leptin. Similar to the animal model leptin concentrations in most of the obese patients are higher compared to normal-weight persons. The postulated leptin resistance is one major target in the search for a better understanding of obesity and the development of pharmacological tools to treat this spreading disease.

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Year:  2003        PMID： 12605342     DOI： 10.1055/s-2003-37492

Source DB:  PubMed          Journal:  Exp Clin Endocrinol Diabetes        ISSN： 0947-7349            Impact factor:   2.949


  12 in total

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