OBJECTIVE: To further evaluate the controversial putative association between a Ser9Gly variant in the first exon of the dopamine D3 receptor gene (DRD3) and schizophrenia. METHODS: Swedish patients with schizophrenia ( n=156) and control subjects ( n=463) were assessed for the DRD3 Ser9Gly variant. Meta-analyses including previous and the present Swedish case-control results were performed. RESULTS: No significant difference between the Swedish patients and controls were found, but there was an association between DRD3 Ser9Gly Ser/Ser and homozygous genotypes and response to anti-psychotic drugs. This finding was supported by an incomplete meta-analysis. In a meta-analysis of all case-control studies comprising 8761 subjects the association between DRD3 Ser9Gly homozygosity and schizophrenia ( =4.96, degree of freedom=1, p <0.05, odds ratio=1.10, 95% confidence interval=1.01-1.20) persisted. However, the previously proposed association between the Ser/Ser genotype and schizophrenia was not significant (chi2 =2.71, degree of freedom=1, p>0.05, odds ratio=1.08, 95% confidence interval=0.99-1.17). CONCLUSIONS: Whereas the present Swedish case-control analysis did not yield any evidence for association with the diagnosis, the present meta-analysis suggests that the DRD3 gene confer susceptibility to schizophrenia. Reasons for the discrepancies between prior studies are discussed.
OBJECTIVE: To further evaluate the controversial putative association between a Ser9Gly variant in the first exon of the dopamine D3 receptor gene (DRD3) and schizophrenia. METHODS: Swedish patients with schizophrenia ( n=156) and control subjects ( n=463) were assessed for the DRD3 Ser9Gly variant. Meta-analyses including previous and the present Swedish case-control results were performed. RESULTS: No significant difference between the Swedish patients and controls were found, but there was an association between DRD3 Ser9Gly Ser/Ser and homozygous genotypes and response to anti-psychotic drugs. This finding was supported by an incomplete meta-analysis. In a meta-analysis of all case-control studies comprising 8761 subjects the association between DRD3 Ser9Gly homozygosity and schizophrenia ( =4.96, degree of freedom=1, p <0.05, odds ratio=1.10, 95% confidence interval=1.01-1.20) persisted. However, the previously proposed association between the Ser/Ser genotype and schizophrenia was not significant (chi2 =2.71, degree of freedom=1, p>0.05, odds ratio=1.08, 95% confidence interval=0.99-1.17). CONCLUSIONS: Whereas the present Swedish case-control analysis did not yield any evidence for association with the diagnosis, the present meta-analysis suggests that the DRD3 gene confer susceptibility to schizophrenia. Reasons for the discrepancies between prior studies are discussed.
Authors: Thomas W Weickert; Terry E Goldberg; Michael F Egan; Jose A Apud; Martijn Meeter; Catherine E Myers; Mark A Gluck; Daniel R Weinberger Journal: Biol Psychiatry Date: 2010-02-20 Impact factor: 13.382
Authors: Michael E Talkowski; George Kirov; Mikhil Bamne; Lyudmila Georgieva; Gonzalo Torres; Hader Mansour; Kodavali V Chowdari; Vihra Milanova; Joel Wood; Lora McClain; Konasale Prasad; Brian Shirts; Jianping Zhang; Michael C O'Donovan; Michael J Owen; Bernie Devlin; Vishwajit L Nimgaonkar Journal: Hum Mol Genet Date: 2007-11-27 Impact factor: 6.150
Authors: Michael E Talkowski; Howard Seltman; Anne S Bassett; Linda M Brzustowicz; Xiangning Chen; Kodavali V Chowdari; David A Collier; Quirino Cordeiro; Aiden P Corvin; Smita N Deshpande; Michael F Egan; Michael Gill; Kenneth S Kendler; George Kirov; Leonard L Heston; Pat Levitt; David A Lewis; Tao Li; Karoly Mirnics; Derek W Morris; Nadine Norton; Michael C O'Donovan; Michael J Owen; Christian Richard; Prachi Semwal; Janet L Sobell; David St Clair; Richard E Straub; B K Thelma; Homero Vallada; Daniel R Weinberger; Nigel M Williams; Joel Wood; Feng Zhang; Bernie Devlin; Vishwajit L Nimgaonkar Journal: Biol Psychiatry Date: 2006-04-21 Impact factor: 13.382