BACKGROUND: A decreased expression of glutathione peroxidase mRNA, an antioxidant enzyme, was previously observed in thyroid anaplastic carcinomas. METHODS: To clarify the expression of antioxidant-related enzymes in thyroid anaplastic carcinomas, the expression levels of catalase, copper and zinc superoxide dismutase and manganese superoxide dismutase mRNA in 85 benign and malignant thyroid tissues were measured by means of real-time quantitative reverse transcription-polymerase chain reaction. RESULTS: Decreased expression levels of catalase and copper and zinc superoxide dismutase mRNAs, but not manganese mRNA, were observed in five anaplastic carcinomas compared with normal thyroid tissues and differentiated tumors. CONCLUSION: These results suggest the possibility that anaplastic carcinoma cells are more likely to suffer damage by oxygen free radicals than normal thyroid cells or differentiated tumor cells.
BACKGROUND: A decreased expression of glutathione peroxidase mRNA, an antioxidant enzyme, was previously observed in thyroid anaplastic carcinomas. METHODS: To clarify the expression of antioxidant-related enzymes in thyroid anaplastic carcinomas, the expression levels of catalase, copper and zinc superoxide dismutase and manganese superoxide dismutase mRNA in 85 benign and malignant thyroid tissues were measured by means of real-time quantitative reverse transcription-polymerase chain reaction. RESULTS: Decreased expression levels of catalase and copper and zinc superoxide dismutase mRNAs, but not manganese mRNA, were observed in five anaplastic carcinomas compared with normal thyroid tissues and differentiated tumors. CONCLUSION: These results suggest the possibility that anaplastic carcinoma cells are more likely to suffer damage by oxygen free radicals than normal thyroid cells or differentiated tumor cells.
Authors: D Russo; A Bisca; M Celano; F Talamo; F Arturi; A Scipioni; I Presta; S Bulotta; E Ferretti; S Filetti; A Scaloni; G Damante; G Tell Journal: J Endocrinol Invest Date: 2005-02 Impact factor: 4.256
Authors: Fabiana Franchini; Giuseppe Palatucci; Annamaria Colao; Paola Ungaro; Paolo Emidio Macchia; Immacolata Cristina Nettore Journal: Int J Environ Res Public Health Date: 2022-01-20 Impact factor: 3.390
Authors: Alessandra di Masi; Rosario Luigi Sessa; Ylenia Cerrato; Gianni Pastore; Barbara Guantario; Roberto Ambra; Michael Di Gioacchino; Armida Sodo; Martina Verri; Pierfilippo Crucitti; Filippo Longo; Anda Mihaela Naciu; Andrea Palermo; Chiara Taffon; Filippo Acconcia; Fabrizio Bianchi; Paolo Ascenzi; Maria Antonietta Ricci; Anna Crescenzi Journal: Antioxidants (Basel) Date: 2022-07-27