Literature DB >> 12603204

Non-classical pathways of cell-mediated allograft rejection: new challenges for tolerance induction?

Alain Le Moine1, Michel Goldman.   

Abstract

Allograft rejection results from separate pathways primarily controlled by CD4+ T cells. Refinement of transplantation models together with investigations on rejection occurring despite co-stimulation blockade revealed unexpected pathways involving CD8+ T cells, NK cells and Th2 cytokines. In this minireview, we discuss these non-classical pathways of allograft rejection and their relevance for the induction of tolerance in the clinics.

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Year:  2003        PMID： 12603204     DOI： 10.1034/j.1600-6143.2002.00026.x

Source DB:  PubMed          Journal:  Am J Transplant        ISSN： 1600-6135            Impact factor:   8.086


  7 in total

1.  Interferon gamma licensing of human dendritic cells in T-helper-independent CD8+ alloimmunity.

Authors:  Roxane Lemoine; Florence Velge-Roussel; Florence Herr; Romain Felix; Hubert Nivet; Yvon Lebranchu; Christophe Baron
Journal:  Blood       Date:  2010-07-19       Impact factor: 22.113

2.  Loss of transgene following ex vivo gene transfer is associated with a dominant Th2 response: implications for cutaneous gene therapy.

Authors:  Zhenmei Lu; Soosan Ghazizadeh
Journal:  Mol Ther       Date:  2007-03-13       Impact factor: 11.454

3.  Induction of mixed chimerism using combinatory cell-based immune modulation with mesenchymal stem cells and regulatory T cells for solid-organ transplant tolerance.

Authors:  Keon-Il Im; Min-Jung Park; Nayoun Kim; Jung-Yeon Lim; Hyun-Sil Park; Sung-Hee Lee; Young-Sun Nam; Eun-Sol Lee; Jung-Ho Lee; Mi-La Cho; Seok-Goo Cho
Journal:  Stem Cells Dev       Date:  2014-06-26       Impact factor: 3.272

4.  Cytotoxic effector function of CD4-independent, CD8(+) T cells is mediated by TNF-α/TNFR.

Authors:  Jason M Zimmerer; Phillip H Horne; Lori A Fiessinger; Mason G Fisher; Thomas A Pham; Samiya L Saklayen; Ginny L Bumgardner
Journal:  Transplantation       Date:  2012-12-15       Impact factor: 4.939

5.  Transplant acceptance following anti-CD4 versus anti-CD40L therapy: evidence for differential maintenance of graft-reactive T cells.

Authors:  S C Wood; G Lu; B E Burrell; D K Bishop
Journal:  Am J Transplant       Date:  2008-10       Impact factor: 8.086

6.  CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice.

Authors:  Bryna E Burrell; Keri Csencsits; Guanyi Lu; Svetlana Grabauskiene; D Keith Bishop
Journal:  J Immunol       Date:  2008-09-15       Impact factor: 5.422

7.  IL-21 is an antitolerogenic cytokine of the late-phase alloimmune response.

Authors:  Alessandra Petrelli; Michele Carvello; Andrea Vergani; Kang Mi Lee; Sara Tezza; Ming Du; Sonja Kleffel; Liu Chengwen; Bechara G Mfarrej; Patrick Hwu; Antonio Secchi; Warren J Leonard; Deborah Young; Mohamed H Sayegh; James F Markmann; Allan J Zajac; Paolo Fiorina
Journal:  Diabetes       Date:  2011-10-19       Impact factor: 9.461
  7 in total

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