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Literature DB >> 12602839

Taking St John's wort during pregnancy.

Abstract

QUESTION: A 23-year-old patient of mine has been taking St John's wort for postpartum depression for about 2 years. She is now planning her second pregnancy. Is she or her fetus at risk if she continues to take the herbal therapy? ANSWER: Despite the widespread availability and use of St John's wort and extensive research on the herb, there are almost no data on reproductive safety. At this stage, therefore, St John's wort cannot be recommended as safe therapy during pregnancy.

Entities: Disease Species

Mesh：

Substances：
Plant Extracts

Year: 2003 PMID： 12602839 PMCID： PMC2214117

Source DB: PubMed Journal: Can Fam Physician ISSN： 0008-350X Impact factor: 3.275

11 in total

1. Effect of antenatal exposure to Saint John's wort (Hypericum) on neurobehavior of developing mice.

Authors: W F Rayburn; H D Christensen; C L Gonzalez
Journal: Am J Obstet Gynecol Date: 2000-11 Impact factor: 8.661

2. Attitudes and practices of physicians and naturopaths toward herbal products, including use during pregnancy and lactation.

Authors: A Einarson; T Lawrimore; P Brand; M Gallo; C Rotatone; G Koren
Journal: Can J Clin Pharmacol Date: 2000

3. St John's wort during pregnancy.

Authors: L R Grush; A Nierenberg; B Keefe; L S Cohen
Journal: JAMA Date: 1998-11-11 Impact factor: 56.272

Review 4. St John's wort for depression.

Authors: K Linde; C D Mulrow
Journal: Cochrane Database Syst Rev Date: 2000

Review 5. The experimental and clinical pharmacology of St John's Wort (Hypericum perforatum L.).

Authors: P Nathan
Journal: Mol Psychiatry Date: 1999-07 Impact factor: 15.992

Review 6. The risk-benefit profile of commonly used herbal therapies: Ginkgo, St. John's Wort, Ginseng, Echinacea, Saw Palmetto, and Kava.

Authors: Edzard Ernst
Journal: Ann Intern Med Date: 2002-01-01 Impact factor: 25.391

7. Effect of Hypericum perforatum (St John's wort) in major depressive disorder: a randomized controlled trial.

Authors: Jonathan RT Davidson; Kishore M Gadde; John A Fairbank; K Ranga Rama Krishnan; Robert M Califf; Cynthia Binanay; Corette B Parker; Norma Pugh; Tyler D Hartwell; Benedetto Vitiello; Louise Ritz; Joanne Severe; Jonathan O Cole; Charles de Battista; P Murali Doraiswamy; John P Feighner; Paul Keck; Jeffrey Kelsey; Khae-Ming Lin; Peter D Londborg; Charles B Nemeroff; Alan F Schatzberg; David V Sheehan; Ram K Srivastava; Leslie Taylor; Madhukar H Trivedi; Richard H Weisler
Journal: JAMA Date: 2002-04-10 Impact factor: 56.272

Taking St John's wort during pregnancy.

1. Effect of antenatal exposure to Saint John's wort (Hypericum) on neurobehavior of developing mice.

2. Attitudes and practices of physicians and naturopaths toward herbal products, including use during pregnancy and lactation.

3. St John's wort during pregnancy.

Review 4. St John's wort for depression.

Review 5. The experimental and clinical pharmacology of St John's Wort (Hypericum perforatum L.).

Review 6. The risk-benefit profile of commonly used herbal therapies: Ginkgo, St. John's Wort, Ginseng, Echinacea, Saw Palmetto, and Kava.

7. Effect of Hypericum perforatum (St John's wort) in major depressive disorder: a randomized controlled trial.

8. Effect of prenatally administered hypericum (St John's wort) on growth and physical maturation of mouse offspring.

9. Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract.

10. Benefits and risks of the hypericum extract LI 160: drug monitoring study with 3250 patients.

1. Maternal depression and child development.