| Literature DB >> 12601549 |
Hisaki Nagai1, Tetsuji Naka, Yoshie Terada, Toshiaki Komazaki, Aya Yabe, Enjing Jin, Oichi Kawanami, Tadamitsu Kishimoto, Noboru Konishi, Mitsutoshi Nakamura, Yasuhito Kobayashi, Mitsuru Emi.
Abstract
We recently demonstrated inactivation in hepatocellular carcinomas (HCCs) of the gene encoding SOCS1/JAB1/SSI-1, a JAK-binding protein that regulates the JAK/STAT signal-transduction pathway. In a follow-up immunochemical investigation of expression of SOCS-1 in hepatoblastomas (HBLs), the protein was markedly reduced in half of the HBL tumors we examined. CpG-rich regions upstream of the SOCS-1 gene were hypermehylated in 7 of the 15 HBL cases. The results suggest that hypermethylation may play an important role in silencing the SOCS-1 gene, not only in adult HCCs, but also in liver tumors arising in childhood.Entities:
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Year: 2003 PMID： 12601549 DOI： 10.1007/s100380300008
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172