Literature DB >> 12601116

Activated CD8+ T cells in secondary progressive MS secrete lymphotoxin.

Guy J Buckle1, Per Höllsberg, David A Hafler.   

Abstract

The authors compared the functional activation state and cytokine secretion profile of CD8+ T cells in patients with relapsing-remitting and secondary progressive (SP) MS to those in normal controls. In addition, they examined cytokine secretion in relationship to single nucleotide polymorphism (SNP) analysis of cytokine genes. A significant increase in lymphotoxin secretion from anti-CD3-stimulated CD8+ T cells was observed in patients with SPMS as compared to normal controls. The authors found no significant differences in SNP frequency or in secretion of other cytokines.

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Year:  2003        PMID： 12601116     DOI： 10.1212/01.wnl.0000048204.89346.30

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  8 in total

1.  A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT.

Authors:  Jennifer L Gommerman; Keith Giza; Stuart Perper; Irene Sizing; Apinya Ngam-Ek; Cheryl Nickerson-Nutter; Jeffrey L Browning
Journal:  J Clin Invest       Date:  2003-09       Impact factor: 14.808

2.  Cellular sources of dysregulated cytokines in relapsing-remitting multiple sclerosis.

Authors:  Jeppe Romme Christensen; Lars Börnsen; Dan Hesse; Martin Krakauer; Per Soelberg Sørensen; Helle Bach Søndergaard; Finn Sellebjerg
Journal:  J Neuroinflammation       Date:  2012-09-14       Impact factor: 8.322

3.  Is multiple sclerosis an autoimmune disease?

Authors:  Bharath Wootla; Makoto Eriguchi; Moses Rodriguez
Journal:  Autoimmune Dis       Date:  2012-05-16

4.  Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis.

Authors:  Cory M Willis; Alexandra M Nicaise; Antoine Menoret; Jae Kyu Ryu; Andrew S Mendiola; Evan R Jellison; Maria I Givogri; David K Han; Ernesto R Bongarzone; Katerina Akassoglou; Anthony T Vella; Stephen J Crocker
Journal:  Proc Natl Acad Sci U S A       Date:  2019-05-08       Impact factor: 11.205

5.  c-Met is expressed by highly autoreactive encephalitogenic CD8+ cells.

Authors:  Mahdia Benkhoucha; Isis Senoner; Patrice H Lalive
Journal:  J Neuroinflammation       Date:  2020-02-19       Impact factor: 8.322

Review 6.  HGF and MET: From Brain Development to Neurological Disorders.

Authors:  Claudia Desole; Simona Gallo; Annapia Vitacolonna; Francesca Montarolo; Antonio Bertolotto; Denis Vivien; Paolo Comoglio; Tiziana Crepaldi
Journal:  Front Cell Dev Biol       Date:  2021-06-09

7.  Systemic inflammation in progressive multiple sclerosis involves follicular T-helper, Th17- and activated B-cells and correlates with progression.

Authors:  Jeppe Romme Christensen; Lars Börnsen; Rikke Ratzer; Fredrik Piehl; Mohsen Khademi; Tomas Olsson; Per Soelberg Sørensen; Finn Sellebjerg
Journal:  PLoS One       Date:  2013-03-01       Impact factor: 3.240

8.  Differential Frequency of CD8+ T Cell Subsets in Multiple Sclerosis Patients with Various Clinical Patterns.

Authors:  Zahra Salehi; Rozita Doosti; Masoumeh Beheshti; Ehsan Janzamin; Mohammad Ali Sahraian; Maryam Izad
Journal:  PLoS One       Date:  2016-07-28       Impact factor: 3.240
  8 in total

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