| Literature DB >> 12599465 |
Guido Koch1, Olivier Loiseleur, Daniel Fuentes, Andrea Jantsch, Karl-Heinz Altmann.
Abstract
[formula: see text] The development of a highly diastereoselective addition of the titanium enolate derived from ketone 1 to aldehyde 2 offers an efficient entry to the total synthesis of the epothilone family. The new aldol process is robust and tolerates a wide range of functional groups.Entities:
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Year: 2002 PMID： 12599465 DOI： 10.1021/ol026480b
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005