Literature DB >> 12599462

Highly enantioselective 1,4-addition of diorganozinc reagents to cyclic enones using chiral diphosphite ligands derived from H8-binaphthol.

Liang Liang1, Terry T L Au-Yeung, Albert S C Chan.   

Abstract

[formula: see text] High enantioselectivities have been achieved in the 1,4-addition of dialkylzincs to 2-cyclopentenone, 2-cyclohexenone, and 2-cycloheptenone with ee values up to 99% by using chiral aryl diphosphite ligands derived from H8-binaphthol.

Entities:  

Year:  2002        PMID： 12599462     DOI： 10.1021/ol026581+

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  1 in total

1.  Enantioselective synthesis of all-carbon quaternary stereogenic centers by catalytic asymmetric conjugate additions of alkyl and aryl aluminum reagents to five-, six-, and seven-membered-ring beta-substituted cyclic enones.

Authors:  Tricia L May; M Kevin Brown; Amir H Hoveyda
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336
  1 in total

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