| Literature DB >> 12599069 |
Thomas Kossmann1, M Cristina Morganti-Kossmann, Jan M Orenstein, William J Britt, Sharon M Wahl, Phillip D Smith.
Abstract
Cytomegalovirus (CMV) encephalitis is well documented in immunosuppressed persons, but its pathogenesis has received little investigative attention. The examination of brain tissue from 2 patients with acquired immunodeficiency syndrome who had CMV encephalitis showed colocalization of CMV inclusions and transforming growth factor (TGF)-beta in cells that contained astrocyte-specific glial filaments. To investigate the relationship between CMV and TGF-beta in the brain, an ex vivo murine model of CMV-infected astrocytes was established. Cultures of primary murine (strain FVB/N) astrocytes inoculated with murine (Smith strain) CMV expressed, over time, increasing amounts of infectious CMV in parallel with increasing levels of TGF-beta mRNA and peptide. Astrocyte release of CMV declined in the presence of antibody to TGF-beta and increased substantially after the addition of exogenous TGF-beta. These findings suggest that CMV infection of astrocytes induces the production of TGF-beta, which in turn enhances productive CMV expression.Entities:
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Year: 2003 PMID： 12599069 DOI： 10.1086/373995
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226