Literature DB >> 12599063

Outbreak of meningococcal disease caused by PorA-deficient meningococci.

A van der Ende1, C T P Hopman, W C M Keijzers, L Spanjaard, E B Lodder, P H J van Keulen, J Dankert.   

Abstract

An outbreak of 7 cases of group C meningococcal disease occurred during the last week of July and the first week of August 2001 in the southwestern part of The Netherlands. Characterization of the 7 patients' isolates by various typing methods showed that the isolates were identical, except for the expression of PorA. Isolates from 5 patients were PorA deficient. These results show that transmission of PorA-deficient meningococci occurs and that PorA-deficient meningococci can cause invasive disease. PorA-based meningococcal vaccines may provide limited protection.

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Year:  2003        PMID： 12599063     DOI： 10.1086/367899

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  12 in total

1.  DNA Sequence analysis of the PorB protein of nonserotypeable serogroup C ET-15 meningococci suggests a potential mutational hot spot on their serotype antigens.

Authors:  Dennis K S Law; Averil M Henderson; Raymond S W Tsang
Journal:  J Clin Microbiol       Date:  2004-06       Impact factor: 5.948

Review 2.  Prospects for vaccine prevention of meningococcal infection.

Authors:  Lee H Harrison
Journal:  Clin Microbiol Rev       Date:  2006-01       Impact factor: 26.132

3.  Clonal analysis of Neisseria meningitidis serogroup B strains in South Africa, 2002 to 2006: emergence of new clone ST-4240/6688.

Authors:  Chivonne Moodley; Mignon du Plessis; Kedibone Ndlangisa; Linda de Gouveia; Keith P Klugman; Anne von Gottberg
Journal:  J Clin Microbiol       Date:  2012-09-12       Impact factor: 5.948

4.  Multiple-locus variable-number tandem repeat analysis of Neisseria meningitidis yields groupings similar to those obtained by multilocus sequence typing.

Authors:  Leo M Schouls; Arie van der Ende; Marjolein Damen; Ingrid van de Pol
Journal:  J Clin Microbiol       Date:  2006-04       Impact factor: 5.948

5.  The VR2 epitope on the PorA P1.7-2,4 protein is the major target for the immune response elicited by the strain-specific group B meningococcal vaccine MeNZB.

Authors:  D R Martin; N Ruijne; L McCallum; J O'Hallahan; P Oster
Journal:  Clin Vaccine Immunol       Date:  2006-04

6.  Protective antibody responses elicited by a meningococcal outer membrane vesicle vaccine with overexpressed genome-derived neisserial antigen 1870.

Authors:  Victor C Hou; Oliver Koeberling; Jo Anne Welsch; Dan M Granoff
Journal:  J Infect Dis       Date:  2005-07-15       Impact factor: 5.226

Review 7.  Meningococcal vaccines.

Authors:  Jens U Rüggeberg; Andrew J Pollard
Journal:  Paediatr Drugs       Date:  2004       Impact factor: 3.022

8.  Neisseria meningitidis Lacking the Major Porins PorA and PorB Is Viable and Modulates Apoptosis and the Oxidative Burst of Neutrophils.

Authors:  Ian R Peak; Adrienne Chen; Freda E-C Jen; Courtney Jennings; Benjamin L Schulz; Nigel J Saunders; Arshad Khan; H Steven Seifert; Michael P Jennings
Journal:  J Proteome Res       Date:  2016-07-21       Impact factor: 4.466

9.  Deletion of the meningococcal fetA gene used for antigen sequence typing of invasive and commensal isolates from Germany: frequencies and mechanisms.

Authors:  Heike Claus; Johannes Elias; Christine Meinhardt; Matthias Frosch; Ulrich Vogel
Journal:  J Clin Microbiol       Date:  2007-07-11       Impact factor: 5.948

10.  Phase variation of PorA, a major outer membrane protein, mediates escape of bactericidal antibodies by Neisseria meningitidis.

Authors:  Isfahan Tauseef; Youssif M Ali; Christopher D Bayliss
Journal:  Infect Immun       Date:  2013-02-12       Impact factor: 3.441
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