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Literature DB >> 12599046

Breast-milk infectivity in human immunodeficiency virus type 1-infected mothers.

Barbra A Richardson¹, Grace C John-Stewart, James P Hughes, Ruth Nduati, Dorothy Mbori-Ngacha, Julie Overbaugh, Joan K Kreiss.

Abstract

Human immunodeficiency virus type 1 (HIV-1) is transmitted through blood, genital secretions, and breast milk. The probability of heterosexual transmission of HIV-1 per sex act is.0003-.0015, but little is known regarding the risk of transmission per breast-milk exposure. We evaluated the probability of breast-milk transmission of HIV-1 per liter of breast milk ingested and per day of breast-feeding in a study of children born to HIV-1-infected mothers. The probability of breast-milk transmission of HIV-1 was.00064 per liter ingested and.00028 per day of breast-feeding. Breast-milk infectivity was significantly higher for mothers with more-advanced disease, as measured by prenatal HIV-1 RNA plasma levels and CD4 cell counts. The probability of HIV-1 infection per liter of breast milk ingested by an infant is similar in magnitude to the probability of heterosexual transmission of HIV-1 per unprotected sex act in adults.

Entities: Disease Species

Mesh：

Substances：
RNA, Viral

Year: 2003 PMID： 12599046 PMCID： PMC3382109 DOI： 10.1086/374272

Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226

22 in total

1. Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda.

Authors: R H Gray; M J Wawer; R Brookmeyer; N K Sewankambo; D Serwadda; F Wabwire-Mangen; T Lutalo; X Li; T vanCott; T C Quinn
Journal: Lancet Date: 2001-04-14 Impact factor: 79.321

2. Method of feeding and transmission of HIV-1 from mothers to children by 15 months of age: prospective cohort study from Durban, South Africa.

Authors: A Coutsoudis; K Pillay; L Kuhn; E Spooner; W Y Tsai; H M Coovadia
Journal: AIDS Date: 2001-02-16 Impact factor: 4.177

3. Modeling breastmilk infectivity in HIV-1 infected mothers.

Authors: Barbra A Richardson; James P Hughes
Journal: Biometrics Date: 2003-03 Impact factor: 2.571

4. Statistical analysis of HIV infectivity based on partner studies.

Authors: N P Jewell; S C Shiboski
Journal: Biometrics Date: 1990-12 Impact factor: 2.571

5. Effect of breastfeeding and formula feeding on transmission of HIV-1: a randomized clinical trial.

Authors: R Nduati; G John; D Mbori-Ngacha; B Richardson; J Overbaugh; A Mwatha; J Ndinya-Achola; J Bwayo; F E Onyango; J Hughes; J Kreiss
Journal: JAMA Date: 2000-03-01 Impact factor: 56.272

6. Modeling HIV infectivity: must sex acts be counted?

Authors: E H Kaplan
Journal: J Acquir Immune Defic Syndr (1988) Date: 1990

7. Heterogeneity in the probability of HIV transmission per sexual contact: the case of male-to-female transmission in penile-vaginal intercourse.

Authors: J A Wiley; S J Herschkorn; N S Padian
Journal: Stat Med Date: 1989-01 Impact factor: 2.373

8. Correlates of mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission: association with maternal plasma HIV-1 RNA load, genital HIV-1 DNA shedding, and breast infections.

Authors: G C John; R W Nduati; D A Mbori-Ngacha; B A Richardson; D Panteleeff; A Mwatha; J Overbaugh; J Bwayo; J O Ndinya-Achola; J K Kreiss
Journal: J Infect Dis Date: 2000-12-15 Impact factor: 5.226

9. HIV transmission through breastfeeding: a study in Malawi.

Authors: P G Miotti; T E Taha; N I Kumwenda; R Broadhead; L A Mtimavalye; L Van der Hoeven; J D Chiphangwi; G Liomba; R J Biggar
Journal: JAMA Date: 1999-08-25 Impact factor: 56.272

10. HIV-1 transmission through breast-milk: appraisal of risk according to duration of feeding.

Authors: M de Martino; P A Tovo; A E Tozzi; P Pezzotti; L Galli; S Livadiotti; D Caselli; E Massironi; E Ruga; F Fioredda
Journal: AIDS Date: 1992-09 Impact factor: 4.177

26 in total

1. Breast Milk of HIV-Positive Mothers Has Potent and Species-Specific In Vivo HIV-Inhibitory Activity.

Authors: Angela Wahl; Caroline Baker; Rae Ann Spagnuolo; Lisa W Stamper; Genevieve G Fouda; Sallie R Permar; Katie Hinde; Louise Kuhn; Lars Bode; Grace M Aldrovandi; J Victor Garcia
Journal: J Virol Date: 2015-08-19 Impact factor: 5.103

2. The breadth and potency of passively acquired human immunodeficiency virus type 1-specific neutralizing antibodies do not correlate with the risk of infant infection.

Authors: John B Lynch; Ruth Nduati; Catherine A Blish; Barbra A Richardson; Jennifer M Mabuka; Zahra Jalalian-Lechak; Grace John-Stewart; Julie Overbaugh
Journal: J Virol Date: 2011-03-16 Impact factor: 5.103

Review 3. HIV-exposed uninfected children: a growing population with a vulnerable immune system?

Authors: L Afran; M Garcia Knight; E Nduati; B C Urban; R S Heyderman; S L Rowland-Jones
Journal: Clin Exp Immunol Date: 2014-04 Impact factor: 4.330

4. Breast milk HIV-1 suppression and decreased transmission: a randomized trial comparing HIVNET 012 nevirapine versus short-course zidovudine.

Authors: Michael H Chung; James N Kiarie; Barbra A Richardson; Dara A Lehman; Julie Overbaugh; Grace C John-Stewart
Journal: AIDS Date: 2005-09-02 Impact factor: 4.177

5. Temporal reduction of HIV type 1 viral load in breast milk by single-dose nevirapine during prevention of MTCT.

Authors: Raabya Rossenkhan; Thumbi Ndung'u; Teresa K Sebunya; Jose E Hagan; Roger Shapiro; Vladimir Novitsky; Sikhulile M Moyo; Ibou Thior; Shahin Lockman; Rebecca Mitchell; Soyeon Kim; Rosemary Musonda; Erik van Widenfelt; Joseph Makhema; M Essex
Journal: AIDS Res Hum Retroviruses Date: 2009-12 Impact factor: 2.205

10. Modeling the effects of different infant feeding strategies on infant survival and mother-to-child transmission of HIV.

Authors: Jay S Ross; Miriam H Labbok
Journal: Am J Public Health Date: 2004-07 Impact factor: 9.308