Literature DB >> 12598258

The induction of apoptosis by local anesthetics: a comparison between lidocaine and ropivacaine.

Emmanuel Boselli1, Frédéric Duflo, Richard Debon, Bernard Allaouchiche, Dominique Chassard, Luc Thomas, Jacques Portoukalian.   

Abstract

IMPLICATIONS: This study suggests that lidocaine can induce apoptosis (detected by dual staining with Annexin V and propidium iodide) on T-cell line cultures in a time-dependent manner. This was not observed with ropivacaine.

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Year:  2003        PMID： 12598258     DOI： 10.1213/01.ane.0000047201.85815.9d

Source DB:  PubMed          Journal:  Anesth Analg        ISSN： 0003-2999            Impact factor:   5.108


  11 in total

1.  Distinct neurotoxic effects of select local anesthetics on facial nerve injury and recovery.

Authors:  Susanna C Byram; Samantha E Bialek; Vicki A Husak; Daniel Balcarcel; James Park; Jacquelyn Dang; Eileen M Foecking
Journal:  Restor Neurol Neurosci       Date:  2020       Impact factor: 2.406

2.  Bupivacaine causes cytotoxicity in mouse C2C12 myoblast cells: involvement of ERK and Akt signaling pathways.

Authors:  Joseph M Maurice; Yan Gan; Fan-xin Ma; Yong-chang Chang; Michael Hibner; Yao Huang
Journal:  Acta Pharmacol Sin       Date:  2010-03-15       Impact factor: 6.150

3.  Lidocaine down-regulates nuclear factor-kappaB signalling and inhibits cytokine production and T cell proliferation.

Authors:  A Lahat; S Ben-Horin; S B Horin; A Lang; E Fudim; O Picard; Y Chowers
Journal:  Clin Exp Immunol       Date:  2008-03-18       Impact factor: 4.330

4.  Evaluation of spinal toxicity and long-term spinal reflex function after intrathecal levobupivaciane in the neonatal rat.

Authors:  Emre Hamurtekin; Bethany L Fitzsimmons; Veronica I Shubayev; Marjorie R Grafe; Ronald Deumens; Tony L Yaksh; Suellen M Walker
Journal:  Anesthesiology       Date:  2013-07       Impact factor: 7.892

5.  Growth inhibition by bupivacaine is associated with inactivation of ribosomal protein S6 kinase 1.

Authors:  Mushtaq Ahmad Beigh; Mehvish Showkat; Basharat Bashir; Asma Bashir; Mahboob ul Hussain; Khurshid Iqbal Andrabi
Journal:  Biomed Res Int       Date:  2014-01-29       Impact factor: 3.411

Review 6.  The Amide Local Anesthetic Lidocaine in Cancer Surgery-Potential Antimetastatic Effects and Preservation of Immune Cell Function? A Narrative Review.

Authors:  Thiên-Nga Chamaraux-Tran; Tobias Piegeler
Journal:  Front Med (Lausanne)       Date:  2017-12-20

7.  Neurotoxicity Comparison of Two Types of Local Anaesthetics: Amide-Bupivacaine versus Ester-Procaine.

Authors:  Xu-Jiao Yu; Wei Zhao; Yu-Jie Li; Feng-Xian Li; Zhong-Jie Liu; Hua-Li Xu; Lu-Ying Lai; Rui Xu; Shi-Yuan Xu
Journal:  Sci Rep       Date:  2017-03-24       Impact factor: 4.379

8.  Protective effects of extracellular polymeric substances from Aphanizomenon flos-aquae on neurotoxicity induced by local anesthetics.

Authors:  Xing Xue; Ying Lv; Yufang Leng; Yan Zhang
Journal:  Exp Ther Med       Date:  2018-07-30       Impact factor: 2.447

9.  Transcriptome sequencing combined with bioinformatics predicts potential genes and pathways associated with bupivacaine-induced apoptosis.

Authors:  Pihong Wei; Te Wang; Shulin Han; Guifen Ma; Shenqiang Gao; Zaiqi Yang
Journal:  Anim Cells Syst (Seoul)       Date:  2017-02-22       Impact factor: 1.815

10.  Voltage-Gated Sodium Channels as Potential Biomarkers and Therapeutic Targets for Epithelial Ovarian Cancer.

Authors:  Iris S Brummelhuis; Stephen J Fiascone; Kathleen T Hasselblatt; Gyorgy Frendl; Kevin M Elias
Journal:  Cancers (Basel)       Date:  2021-10-29       Impact factor: 6.575
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