Literature DB >> 12596862

Old Yellow Enzyme from Candida macedoniensis catalyzes the stereospecific reduction of the C=C bond of ketoisophorone.

Michihiko Kataoka1, Atsushi Kotaka, Akiko Hasegawa, Masaru Wada, Ayumi Yoshizumi, Shigeru Nakamori, Sakayu Shimizu.   

Abstract

Microorganisms were screened for ones that reduced 3,5,5-trimethyl-2-cyclohexene-1,4-dione (ketoisophorone; KIP), and several strains were found to produce (6R)-2,2,6-trimethylcyclohexane-1,4-dione (levodione). The enzyme catalyzing the reduction of the C=C bond of KIP to yield (6R)-levodione was isolated from Candida macedoniensis AKU4588. The results of primary structural analysis and its enzymatic properties suggested that the enzyme might be an Old Yellow Enzyme family protein.

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Year:  2002        PMID： 12596862     DOI： 10.1271/bbb.66.2651

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  7 in total

1.  Cloning and expression of a novel NADP(H)-dependent daidzein reductase, an enzyme involved in the metabolism of daidzein, from equol-producing Lactococcus strain 20-92.

Authors:  Yoshikazu Shimada; Setsuko Yasuda; Masayuki Takahashi; Takashi Hayashi; Norihiro Miyazawa; Ikutaro Sato; Yasuhiro Abiru; Shigeto Uchiyama; Haretsugu Hishigaki
Journal:  Appl Environ Microbiol       Date:  2010-07-16       Impact factor: 4.792

2.  Production of a doubly chiral compound, (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone, by two-step enzymatic asymmetric reduction.

Authors:  Masaru Wada; Ayumi Yoshizumi; Yumiko Noda; Michihiko Kataoka; Sakayu Shimizu; Hiroshi Takagi; Shigeru Nakamori
Journal:  Appl Environ Microbiol       Date:  2003-02       Impact factor: 4.792

3.  Engineering a nicotinamide mononucleotide redox cofactor system for biocatalysis.

Authors:  William B Black; Linyue Zhang; Wai Shun Mak; Sarah Maxel; Youtian Cui; Edward King; Bonnie Fong; Alicia Sanchez Martinez; Justin B Siegel; Han Li
Journal:  Nat Chem Biol       Date:  2019-11-25       Impact factor: 15.040

Review 4.  Asymmetric bioreduction of activated alkenes to industrially relevant optically active compounds.

Authors:  Christoph K Winkler; Gábor Tasnádi; Dorina Clay; Mélanie Hall; Kurt Faber
Journal:  J Biotechnol       Date:  2012-04-04       Impact factor: 3.307

5.  Identification of a novel ene reductase from Pichia angusta with potential application in (R)-levodione production.

Authors:  Baoqi Zhang; Jiale Sun; Yanqiu Zheng; Xinlei Mao; Jinping Lin; Dongzhi Wei
Journal:  RSC Adv       Date:  2022-05-10       Impact factor: 4.036

6.  Functional characterization and stability improvement of a 'thermophilic-like' ene-reductase from Rhodococcus opacus 1CP.

Authors:  Anika Riedel; Marika Mehnert; Caroline E Paul; Adrie H Westphal; Willem J H van Berkel; Dirk Tischler
Journal:  Front Microbiol       Date:  2015-10-01       Impact factor: 5.640

7.  Highly stable and reusable immobilized formate dehydrogenases: Promising biocatalysts for in situ regeneration of NADH.

Authors:  Barış Binay; Dilek Alagöz; Deniz Yildirim; Ayhan Çelik; S Seyhan Tükel
Journal:  Beilstein J Org Chem       Date:  2016-02-12       Impact factor: 2.883
  7 in total

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