| Literature DB >> 12595900 |
C Favre1, A Gérard, E Clauzier, P Pontarotti, D Olive, J A Nunès.
Abstract
Dok proteins are adapter proteins involved in signal transduction. Several intracellular proteins expressed in lymphocytes meet the criteria of membrane-associated adapter proteins such as members of the Dok family. To understand the role and the formation of multiprotein networks involving Dok proteins in T lymphocytes, we search for potential additional members of this family. Here, we describe the two new human dok-related genes DOK4 and DOK5 and present data showing the expression of DOK4 and DOK5 genes in T cells. These genes are the orthologues of mouse Dok4 and Dok5 genes. Based on analysis of phylogenetic trees and exon/intron structure of Dok family members, DOK4 and DOK5 define a subfamily within dok genes distinct from DOK1, DOK2 and DOK3. So, Dok-4 and Dok-5 molecules constitute a new group of adapter proteins in T cells, requiring further functional analysis.Entities:
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Year: 2003 PMID： 12595900 DOI： 10.1038/sj.gene.6363891
Source DB: PubMed Journal: Genes Immun ISSN： 1466-4879 Impact factor: 2.676