Literature DB >> 12595478

Role of interleukin-6 in the control of acute and chronic Giardia lamblia infections in mice.

Ping Zhou1, Erqiu Li, Nannan Zhu, Jason Robertson, Theodore Nash, Steven M Singer.   

Abstract

In this study, we investigated the role of interleukin-6 (IL-6) in Giardia lamblia infections in mice. Elevated IL-6 expression was found in wild-type mice 15 days postinfection. Furthermore, IL-6-deficient mice controlled infections only slowly although normal immunoglobulin A production was observed. Thus, IL-6 is necessary for early control of acute G. lamblia infections.

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Year:  2003        PMID： 12595478      PMCID： PMC148826          DOI： 10.1128/IAI.71.3.1566-1568.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  19 in total

1.  Central importance of immunoglobulin A in host defense against Giardia spp.

Authors:  T Dianne Langford; Michael P Housley; Marianne Boes; Jianzhu Chen; Martin F Kagnoff; Frances D Gillin; Lars Eckmann
Journal:  Infect Immun       Date:  2002-01       Impact factor: 3.441

2.  Constructing polycompetitor cDNAs for quantitative PCR.

Authors:  S L Reiner; S Zheng; D B Corry; R M Locksley
Journal:  J Immunol Methods       Date:  1993-09-27       Impact factor: 2.303

Review 3.  Giardia and giardiasis.

Authors:  R C Thompson; J A Reynoldson; A H Mendis
Journal:  Adv Parasitol       Date:  1993       Impact factor: 3.870

4.  Jejunal brush border microvillous alterations in Giardia muris-infected mice: role of T lymphocytes and interleukin-6.

Authors:  K G Scott; M R Logan; G M Klammer; D A Teoh; A G Buret
Journal:  Infect Immun       Date:  2000-06       Impact factor: 3.441

5.  T-cell-dependent control of acute Giardia lamblia infections in mice.

Authors:  S M Singer; T E Nash
Journal:  Infect Immun       Date:  2000-01       Impact factor: 3.441

6.  Giardia lamblia infections in adult mice.

Authors:  L G Byrd; J T Conrad; T E Nash
Journal:  Infect Immun       Date:  1994-08       Impact factor: 3.441

7.  Interleukin-6-deficient mice are highly susceptible to Listeria monocytogenes infection: correlation with inefficient neutrophilia.

Authors:  S A Dalrymple; L A Lucian; R Slattery; T McNeil; D M Aud; S Fuchino; F Lee; R Murray
Journal:  Infect Immun       Date:  1995-06       Impact factor: 3.441

8.  Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.

Authors:  T Hirano; K Yasukawa; H Harada; T Taga; Y Watanabe; T Matsuda; S Kashiwamura; K Nakajima; K Koyama; A Iwamatsu
Journal:  Nature       Date:  1986 Nov 6-12       Impact factor: 49.962

9.  Serological analysis of antigenic heterogeneity of Giardia lamblia variant surface proteins.

Authors:  N Müller; S Stäger; B Gottstein
Journal:  Infect Immun       Date:  1996-04       Impact factor: 3.441

10.  Clearance of Giardia muris infection requires helper/inducer T lymphocytes.

Authors:  M F Heyworth; J R Carlson; T H Ermak
Journal:  J Exp Med       Date:  1987-06-01       Impact factor: 14.307
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  38 in total

1.  Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice.

Authors:  Erqiu Li; Ping Zhou; Steven M Singer
Journal:  J Immunol       Date:  2006-01-01       Impact factor: 5.422

2.  Giardia lamblia-induced changes in gene expression in differentiated Caco-2 human intestinal epithelial cells.

Authors:  Katarina Roxström-Lindquist; Emma Ringqvist; Daniel Palm; Staffan Svärd
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

3.  Adaptive immune response in symptomatic and asymptomatic enteric protozoal infection: evidence for a determining role of parasite genetic heterogeneity in host immunity to human giardiasis.

Authors:  Zahra Babaei; Najmeh Malihi; Naser Zia-Ali; Iraj Sharifi; Mohammad A Mohammadi; Martin F Kagnoff; Lars Eckmann; Steven M Singer; Shahram Solaymani-Mohammadi
Journal:  Microbes Infect       Date:  2016-07-08       Impact factor: 2.700

Review 4.  Giardia duodenalis: the double-edged sword of immune responses in giardiasis.

Authors:  Shahram Solaymani-Mohammadi; Steven M Singer
Journal:  Exp Parasitol       Date:  2010-06-18       Impact factor: 2.011

Review 5.  The immunology of parasite infections in immunocompromised hosts.

Authors:  T Evering; L M Weiss
Journal:  Parasite Immunol       Date:  2006-11       Impact factor: 2.280

6.  Giardia duodenalis: dendritic cell defects in IL-6 deficient mice contribute to susceptibility to intestinal infection.

Authors:  Joel D Kamda; Theodore E Nash; Steven M Singer
Journal:  Exp Parasitol       Date:  2012-01-10       Impact factor: 2.011

7.  Tumour necrosis factor alpha contributes to protection against Giardia lamblia infection in mice.

Authors:  P Zhou; E Li; T Shea-Donohue; S M Singer
Journal:  Parasite Immunol       Date:  2007-07       Impact factor: 2.280

8.  Cytokines, Antibodies, and Histopathological Profiles during Giardia Infection and Variant-Specific Surface Protein-Based Vaccination.

Authors:  Marianela C Serradell; Pablo R Gargantini; Alicia Saura; Sergio R Oms; Lucía L Rupil; Luciana Berod; Tim Sparwasser; Hugo D Luján
Journal:  Infect Immun       Date:  2018-05-22       Impact factor: 3.441

9.  IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens.

Authors:  Sara M Dann; Martina E Spehlmann; Dustin C Hammond; Mitsutoshi Iimura; Koji Hase; Lillian J Choi; Elaine Hanson; Lars Eckmann
Journal:  J Immunol       Date:  2008-05-15       Impact factor: 5.422

10.  Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia.

Authors:  Joel Désiré Kamda; Steven M Singer
Journal:  Infect Immun       Date:  2008-12-01       Impact factor: 3.441
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