Literature DB >> 12595474

The zinc-dependent major histocompatibility complex class II binding site of streptococcal pyrogenic exotoxin C is critical for maximal superantigen function and toxic activity.

Timothy J Tripp1, John K McCormick, Jennifer M Webb, Patrick M Schlievert.   

Abstract

The cocrystal structure of streptococcal pyrogenic exotoxin C (SPE C) with HLA-DR2a (DRA*0101,DRB5*0101) revealed a zinc-dependent interaction site through residues 167, 201, and 203 on SPE C and residue 81 on the beta-chain of HLA-DR2a (DRA*0101,DRB5*0101). Mutation of these SPE C residues resulted in dramatically reduced biological activities. Thus, the zinc-dependent major histocompatibility complex II binding site is critical for maximal biological function of SPE C.

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Year:  2003        PMID： 12595474      PMCID： PMC148863          DOI： 10.1128/IAI.71.3.1548-1550.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  14 in total

Review 1.  Toxic shock syndrome and bacterial superantigens: an update.

Authors:  J K McCormick; J M Yarwood; P M Schlievert
Journal:  Annu Rev Microbiol       Date:  2001       Impact factor: 15.500

2.  Distinct T-cell receptor V beta gene usage by human T lymphocytes stimulated with the streptococcal pyrogenic exotoxins and pep M5 protein.

Authors:  M A Tomai; P M Schlievert; M Kotb
Journal:  Infect Immun       Date:  1992-02       Impact factor: 3.441

3.  Crystal structure of microbial superantigen staphylococcal enterotoxin B at 1.5 A resolution: implications for superantigen recognition by MHC class II molecules and T-cell receptors.

Authors:  A C Papageorgiou; H S Tranter; K R Acharya
Journal:  J Mol Biol       Date:  1998-03-20       Impact factor: 5.469

4.  Development of streptococcal pyrogenic exotoxin C vaccine toxoids that are protective in the rabbit model of toxic shock syndrome.

Authors:  J K McCormick; T J Tripp; S B Olmsted; Y V Matsuka; P J Gahr; D H Ohlendorf; P M Schlievert
Journal:  J Immunol       Date:  2000-08-15       Impact factor: 5.422

5.  Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes.

Authors:  Eric J Sundberg; Hongmin Li; Andrea S Llera; John K McCormick; José Tormo; Patrick M Schlievert; Klaus Karjalainen; Roy A Mariuzza
Journal:  Structure       Date:  2002-05       Impact factor: 5.006

6.  Enhancement of host susceptibility to lethal endotoxin shock by staphylococcal pyrogenic exotoxin type C.

Authors:  P M Schlievert
Journal:  Infect Immun       Date:  1982-04       Impact factor: 3.441

7.  Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1.

Authors:  J Kim; R G Urban; J L Strominger; D C Wiley
Journal:  Science       Date:  1994-12-16       Impact factor: 47.728

8.  Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II.

Authors:  Y Li; H Li; N Dimasi; J K McCormick; R Martin; P Schuck; P M Schlievert; R A Mariuzza
Journal:  Immunity       Date:  2001-01       Impact factor: 31.745

9.  Toxic-shock-syndrome toxin 1-induced proliferation of lymphocytes: comparison of the mitogenic response of human, murine, and rabbit lymphocytes.

Authors:  N J Poindexter; P M Schlievert
Journal:  J Infect Dis       Date:  1985-01       Impact factor: 5.226

10.  Fluid replacement protection of rabbits challenged subcutaneous with toxic shock syndrome toxins.

Authors:  P K Lee; J R Deringer; B N Kreiswirth; R P Novick; P M Schlievert
Journal:  Infect Immun       Date:  1991-03       Impact factor: 3.441
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  6 in total

1.  Crystal structure of a dimeric form of streptococcal pyrogenic exotoxin A (SpeA1).

Authors:  Matthew D Baker; Inessa Gendlina; Carleen M Collins; K Ravi Acharya
Journal:  Protein Sci       Date:  2004-08-04       Impact factor: 6.725

2.  The T cell receptor beta-chain second complementarity determining region loop (CDR2beta governs T cell activation and Vbeta specificity by bacterial superantigens.

Authors:  A K M Nur-ur Rahman; Daniel A Bonsor; Christine A Herfst; Fraser Pollard; Michael Peirce; Aaron W Wyatt; Katherine J Kasper; Joaquín Madrenas; Eric J Sundberg; John K McCormick
Journal:  J Biol Chem       Date:  2010-12-02       Impact factor: 5.157

Review 3.  Gram-positive bacterial superantigen outside-in signaling causes toxic shock syndrome.

Authors:  Amanda J Brosnahan; Patrick M Schlievert
Journal:  FEBS J       Date:  2011-05-19       Impact factor: 5.542

Review 4.  Staphylococcal superantigens in colonization and disease.

Authors:  Stacey X Xu; John K McCormick
Journal:  Front Cell Infect Microbiol       Date:  2012-04-17       Impact factor: 5.293

Review 5.  The contribution of group A streptococcal virulence determinants to the pathogenesis of sepsis.

Authors:  Mark Reglinski; Shiranee Sriskandan
Journal:  Virulence       Date:  2013-10-09       Impact factor: 5.882

6.  Control of established colon cancer xenografts using a novel humanized single chain antibody-streptococcal superantigen fusion protein targeting the 5T4 oncofetal antigen.

Authors:  Kelcey G Patterson; Jennifer L Dixon Pittaro; Peter S Bastedo; David A Hess; S M Mansour Haeryfar; John K McCormick
Journal:  PLoS One       Date:  2014-04-15       Impact factor: 3.240
  6 in total

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