Literature DB >> 12594996

Alterations of kynurenic acid content in the retina in response to retinal ganglion cell damage.

Robert Rejdak1, Tomasz Zarnowski, Waldemar A Turski, Tomasz Kocki, Zbigniew Zagorski, Eberhart Zrenner, Frank Schuettauf.   

Abstract

The present study is the first to examine the modulation of retinal kynurenic acid (KYNA) content in response to N-methyl-D-aspartate (NMDA)-induced cell death in adult rat retinal ganglion cells (RGC). Adult Brown Norway rats were intravitreally injected with NMDA or PBS. Surviving RGC were retrogradely labeled with fluorogold and counted in wholemounts of retinas 2, 7 and 14 days after injection. Retinal KYNA content was measured by HPLC at the same time points. RGC numbers decreased significantly 2, 7 and 14 days after NMDA injection if compared to control retinas. KYNA concentration increased significantly two days after NMDA-injection. However, 7 and 14 days after injection retinal KYNA content was found markedly decreased in NMDA-treated eyes as compared to controls. It is conceivable that KYNA deficiency is causally related to the pathology of excitotoxic retinal diseases.

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Year:  2003        PMID： 12594996     DOI： 10.1016/s0042-6989(02)00682-x

Source DB:  PubMed          Journal:  Vision Res        ISSN： 0042-6989            Impact factor:   1.886


  8 in total

1.  Kynurenic acid, an endogenous constituent of rheumatoid arthritis synovial fluid, inhibits proliferation of synoviocytes in vitro.

Authors:  Jolanta Parada-Turska; Wojciech Rzeski; Wojciech Zgrajka; Maria Majdan; Martyna Kandefer-Szerszeń; Waldemar Turski
Journal:  Rheumatol Int       Date:  2005-10-12       Impact factor: 2.631

2.  Kynurenic acid production in cultured bovine aortic endothelial cells. Homocysteine is a potent inhibitor.

Authors:  Katarzyna Wejksza; Wojciech Rzeski; Jolanta Parada-Turska; Barbara Zdzisinska; Robert Rejdak; Tomasz Kocki; Etsuo Okuno; Martyna Kandefer-Szerszen; Eberhart Zrenner; Waldemar A Turski
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-02-10       Impact factor: 3.000

3.  Kynurenic acid synthesis in bovine retinal slices--effect of glutamate agonists.

Authors:  T Zarnowski; M Bialek; R Rejdak; E Zrenner; A Junemann; Z Zagorski; T Kocki; W A Turski
Journal:  J Neural Transm (Vienna)       Date:  2006-02-09       Impact factor: 3.575

4.  The Beneficial Effects of Edible Kynurenic Acid from Marine Horseshoe Crab (Tachypleus tridentatus) on Obesity, Hyperlipidemia, and Gut Microbiota in High-Fat Diet-Fed Mice.

Authors:  Jian Li; Yaqi Zhang; Shen Yang; Zhenhua Lu; Guiling Li; Shangyi Wu; Da-Ren Wu; Jingwen Liu; Bo Zhou; Hui-Min David Wang; Shi-Ying Huang
Journal:  Oxid Med Cell Longev       Date:  2021-05-03       Impact factor: 6.543

Review 5.  Neurodegeneration in Multiple Sclerosis: Symptoms of Silent Progression, Biomarkers and Neuroprotective Therapy-Kynurenines Are Important Players.

Authors:  Dániel Sandi; Zsanett Fricska-Nagy; Krisztina Bencsik; László Vécsei
Journal:  Molecules       Date:  2021-06-05       Impact factor: 4.411

6.  Tryptophan and Kynurenine Pathway Metabolites in Animal Models of Retinal and Optic Nerve Damage: Different Dynamics of Changes.

Authors:  Michal Fiedorowicz; Tomasz Choragiewicz; Sebastian Thaler; Frank Schuettauf; Dominika Nowakowska; Kamila Wojtunik; Michele Reibaldi; Teresio Avitabile; Tomasz Kocki; Waldemar A Turski; Agnieszka Kaminska; Pawel Grieb; Eberhart Zrenner; Robert Rejdak; Mario Damiano Toro
Journal:  Front Physiol       Date:  2019-10-01       Impact factor: 4.566

Review 7.  Kynurenic acid and cancer: facts and controversies.

Authors:  Katarzyna Walczak; Artur Wnorowski; Waldemar A Turski; Tomasz Plech
Journal:  Cell Mol Life Sci       Date:  2019-10-28       Impact factor: 9.261

Review 8.  The Organ of Vision and the Stomatognathic System-Review of Association Studies and Evidence-Based Discussion.

Authors:  Grzegorz Zieliński; Zuzanna Filipiak; Michał Ginszt; Anna Matysik-Woźniak; Robert Rejdak; Piotr Gawda
Journal:  Brain Sci       Date:  2021-12-23
  8 in total

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