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Literature DB >> 12594937

Human papillomavirus therapy for the prevention and treatment of cervical cancer.

Abstract

Cervical carcinoma is associated with human papillomavirus infection. Proliferation of cancer cells depends on the continual expression of the E6 and E7 viral oncogenes. This article includes treatment strategies that can interfere with expression or function of the proteins and immunotherapeutic approaches that can eliminate cells that express E6 and E7 proteins.

Entities: Disease Species

Mesh：

Substances：
Viral Envelope Proteins

Year: 2003 PMID： 12594937 DOI： 10.1007/s11864-003-0012-0

Source DB: PubMed Journal: Curr Treat Options Oncol ISSN： 1534-6277

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References

65 in total

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Authors:
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Journal: J Virol Date: 1999-11 Impact factor: 5.103

Human papillomavirus therapy for the prevention and treatment of cervical cancer.

1. Onyx plans phase III trial of ONYX-015 for head & neck cancer.

2. Gene gun-mediated DNA vaccination induces antitumor immunity against human papillomavirus type 16 E7-expressing murine tumor metastases in the liver and lungs.

3. Killing tumor cells with viruses--a question of specificity.

Review 4. Papillomavirus-like particle vaccines.

5. Chimeric papillomavirus virus-like particles elicit antitumor immunity against the E7 oncoprotein in an HPV16 tumor model.

6. Physical interaction of human papillomavirus virus-like particles with immune cells.

7. Activation of p53 in cervical carcinoma cells by small molecules.

8. Adenovirus-mediated transfer of a wild-type p53 gene and induction of apoptosis in cervical cancer.

Review 9. Human papillomaviruses and associated malignancies.

10. Mucosal but not parenteral immunization with purified human papillomavirus type 16 virus-like particles induces neutralizing titers of antibodies throughout the estrous cycle of mice.