Literature DB >> 1259447

Clofazimine. A new agent for the treatment of pyoderma gangrenosum.

G Michaëlsson, L Molin, S Ohmann, L Gip, B Lindström, M Skogh, I Trolin.   

Abstract

Eight patients had pyoderma gangrenosum. They were given a phendimetrazine tartrate derivative, clofazimine (Lamprene [Britain]), which is a chemotherapeutic agent used mainly in certain mycobacterial infections and which also has phagocytosis-enhancing properties. The effect of this drug was remarkably good, with rapid healing of the lesions commencing 3 to 14 days after treatment was started. The mechanism for the effect of clofazimine in pyoderma gangrenosum is not known.

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Year:  1976        PMID: 1259447

Source DB:  PubMed          Journal:  Arch Dermatol        ISSN: 0003-987X


  8 in total

1.  Treatment of ulcerative colitis.

Authors:  K M De Cock
Journal:  Br Med J       Date:  1979-05-19

2.  Pyoderma gangrenosum: From historical perspectives to emerging investigations.

Authors:  Misty M Hobbs; Alex G Ortega-Loayza
Journal:  Int Wound J       Date:  2020-05-06       Impact factor: 3.315

3.  Treatment of pyoderma gangrenosum with disodium cromoglycate.

Authors:  B Saffouri; B M Hom; J M Mertesdorf; J E Gardiner
Journal:  Dig Dis Sci       Date:  1984-02       Impact factor: 3.199

Review 4.  Effective Strategies for the Management of Pyoderma Gangrenosum.

Authors:  Heidi Goodarzi; Raja K Sivamani; Miki Shirakawa Garcia; Lisa N Wehrli; Hilary Craven; Yoko Ono; Emanual Maverakis
Journal:  Adv Wound Care (New Rochelle)       Date:  2012-10       Impact factor: 4.730

5.  The action of Clofazimine on the level of lysosomal enzymes of cultured macrophages.

Authors:  J Sarracent; C M Finlay
Journal:  Clin Exp Immunol       Date:  1982-04       Impact factor: 4.330

6.  Oxygen metabolism in phagocytes of leprotic patients: enhanced endogenous superoxide dismutase activity and hydroxyl radical generation by clofazimine.

Authors:  Y Niwa; T Sakane; Y Miyachi; M Ozaki
Journal:  J Clin Microbiol       Date:  1984-11       Impact factor: 5.948

7.  'Sticky' neutrophils, pathergic arthritis, and response to heparin in pyoderma gangrenosum complicating ulcerative colitis.

Authors:  A D Dwarakanath; L G Yu; C Brookes; D Pryce; J M Rhodes
Journal:  Gut       Date:  1995-10       Impact factor: 23.059

8.  Superficial Variant of Pyoderma Gangrenosum Successfully Treated with Lower Dose Clofazimine.

Authors:  Alaka J Mohan; Sunitha Balakrishnan; Betsy Ambooken; Kidangazhiathmana Ajithkumar; Neelakandhan Asokan
Journal:  Indian Dermatol Online J       Date:  2022-01-24
  8 in total

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