OBJECTIVE: The purpose of this study was to determine that circulating HLA-DR molecules are important candidates for the monitoring of maternal immunostimulation and immunosuppression. STUDY DESIGN: Concentrations of soluble HLA-DR molecules were estimated in EDTA plasma samples of 61 nonpregnant women, 123 healthy pregnant women in the second trimester, 66 healthy women who were delivered at term, and 136 women who were delivered because of complications such as uncontrollable preterm intrauterine activation, abruptio placentae, intrauterine growth retardation, preeclampsia, and HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome. RESULTS: In comparison to nonpregnant women, the normal course of pregnancy was associated with strongly increasing levels of soluble HLA-DR from second trimester on until term. In comparison to women who were delivered preterm because of uncontrollable intrauterine activation, increased soluble HLA-DR concentrations were detected in case of HELLP syndrome (P <.05), although decreased levels were detected in the case of intrauterine growth retardation, preeclampsia (P <.01), and abruptio placentae (P <.01). CONCLUSION: Dysregulation of the maternal immune response to pregnancy may play an important role in the cause of complicated pregnancies.
OBJECTIVE: The purpose of this study was to determine that circulating HLA-DR molecules are important candidates for the monitoring of maternal immunostimulation and immunosuppression. STUDY DESIGN: Concentrations of soluble HLA-DR molecules were estimated in EDTA plasma samples of 61 nonpregnant women, 123 healthy pregnant women in the second trimester, 66 healthy women who were delivered at term, and 136 women who were delivered because of complications such as uncontrollable preterm intrauterine activation, abruptio placentae, intrauterine growth retardation, preeclampsia, and HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome. RESULTS: In comparison to nonpregnant women, the normal course of pregnancy was associated with strongly increasing levels of soluble HLA-DR from second trimester on until term. In comparison to women who were delivered preterm because of uncontrollable intrauterine activation, increased soluble HLA-DR concentrations were detected in case of HELLP syndrome (P <.05), although decreased levels were detected in the case of intrauterine growth retardation, preeclampsia (P <.01), and abruptio placentae (P <.01). CONCLUSION: Dysregulation of the maternal immune response to pregnancy may play an important role in the cause of complicated pregnancies.
Authors: A Steinborn; E Schmitt; A Kisielewicz; S Rechenberg; N Seissler; K Mahnke; M Schaier; M Zeier; C Sohn Journal: Clin Exp Immunol Date: 2012-01 Impact factor: 4.330
Authors: Lukasz Przybyl; Nadine Haase; Michaela Golic; Julianna Rugor; Maria Emilia Solano; Petra Clara Arck; Martin Gauster; Berthold Huppertz; Christoph Emontzpohl; Christian Stoppe; Jürgen Bernhagen; Lin Leng; Richard Bucala; Herbert Schulz; Arnd Heuser; M Susanne Weedon-Fekjær; Guro M Johnsen; Dirk Peetz; Friedrich C Luft; Anne Cathrine Staff; Dominik N Müller; Ralf Dechend; Florian Herse Journal: Circ Res Date: 2016-05-19 Impact factor: 17.367
Authors: Ray Bahado-Singh; Liona C Poon; Ali Yilmaz; Argyro Syngelaki; Onur Turkoglu; Praveen Kumar; Joseph Kirma; Matthew Allos; Veronica Accurti; Jiansheng Li; Peng Zhao; Stewart F Graham; David R Cool; Kypros Nicolaides Journal: Sci Rep Date: 2017-11-23 Impact factor: 4.379