Richard A Krathen1, Staci Ward, Madeleine Duvic. 1. Division of Internal Medicine, Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Tex 77030-3597, USA.
Abstract
BACKGROUND: Lymphomatoid papulosis (LyP) is a clonal T cell proliferation with large cell histology, a chronic course, and an increased risk of lymphoma. Bexarotene (Targretin) is an RXR-selective retinoid (rexinoid) approved for the cutaneous manifestations of cutaneous T cell lymphoma. OBJECTIVE: To determine whether bexarotene is effective in treating LyP. METHODS: Ten patients with chronic and symptomatic LyP were prospectively treated with oral (n = 3) or topical gel (n = 7) formulations of bexarotene. RESULTS: A favorable response to bexarotene treatment with decreased numbers or duration of lesions was seen in all with objective responses in 8 patients. CONCLUSIONS: Bexarotene may be an effective palliative treatment for LyP, warranting further controlled studies. Copyright 2003 S. Karger AG, Basel
BACKGROUND:Lymphomatoid papulosis (LyP) is a clonal T cell proliferation with large cell histology, a chronic course, and an increased risk of lymphoma. Bexarotene (Targretin) is an RXR-selective retinoid (rexinoid) approved for the cutaneous manifestations of cutaneous T cell lymphoma. OBJECTIVE: To determine whether bexarotene is effective in treating LyP. METHODS: Ten patients with chronic and symptomatic LyP were prospectively treated with oral (n = 3) or topical gel (n = 7) formulations of bexarotene. RESULTS: A favorable response to bexarotene treatment with decreased numbers or duration of lesions was seen in all with objective responses in 8 patients. CONCLUSIONS:Bexarotene may be an effective palliative treatment for LyP, warranting further controlled studies. Copyright 2003 S. Karger AG, Basel
Authors: Neha Mehta; Alan S Wayne; Youn H Kim; Gregory A Hale; Carlos S Alvarado; Patricia Myskowski; Elaine S Jaffe; Klaus J Busam; Melissa Pulitzer; Jeffrey Zwerner; Steven Horwitz Journal: Clin Lymphoma Myeloma Leuk Date: 2011-10-15
Authors: Werner Kempf; Katrin Pfaltz; Maarten H Vermeer; Antonio Cozzio; Pablo L Ortiz-Romero; Martine Bagot; Elise Olsen; Youn H Kim; Reinhard Dummer; Nicola Pimpinelli; Sean Whittaker; Emmilia Hodak; Lorenzo Cerroni; Emilio Berti; Steve Horwitz; H Miles Prince; Joan Guitart; Teresa Estrach; José A Sanches; Madeleine Duvic; Annamari Ranki; Brigitte Dreno; Sonja Ostheeren-Michaelis; Robert Knobler; Gary Wood; Rein Willemze Journal: Blood Date: 2011-08-12 Impact factor: 22.113