Literature DB >> 12591616

Identification of human dehydrodolichyl diphosphate synthase gene.

Shota Endo1, Yuan-Wei Zhang, Seiji Takahashi, Tanetoshi Koyama.   

Abstract

We isolated a cDNA encoding human dehydrodolichyl diphosphate (Dedol-PP) synthase and expressed the gene in a yeast mutant strain SNH23-7D, which is deficient in Dedol-PP synthase activity. The identity of the cloned enzyme was confirmed by functional complementation of SNH23-7D strain together with in vitro Dedol-PP synthase activity assay. Northern blot analysis indicated that testis and kidney expressed Dedol-PP synthase mRNA at high levels.

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Year:  2003        PMID： 12591616     DOI： 10.1016/s0167-4781(02)00628-0

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  18 in total

1.  Nogo-B receptor is necessary for cellular dolichol biosynthesis and protein N-glycosylation.

Authors:  Kenneth D Harrison; Eon Joo Park; Ningguo Gao; Andrew Kuo; Jeffrey S Rush; Charles J Waechter; Mark A Lehrman; William C Sessa
Journal:  EMBO J       Date:  2011-05-13       Impact factor: 11.598

2.  A conserved C-terminal RXG motif in the NgBR subunit of cis-prenyltransferase is critical for prenyltransferase activity.

Authors:  Kariona A Grabińska; Ban H Edani; Eon Joo Park; Jan R Kraehling; William C Sessa
Journal:  J Biol Chem       Date:  2017-08-23       Impact factor: 5.157

3.  Structural elucidation of the cis-prenyltransferase NgBR/DHDDS complex reveals insights in regulation of protein glycosylation.

Authors:  Ban H Edani; Kariona A Grabińska; Rong Zhang; Eon Joo Park; Benjamin Siciliano; Liliana Surmacz; Ya Ha; William C Sessa
Journal:  Proc Natl Acad Sci U S A       Date:  2020-08-12       Impact factor: 11.205

4.  Expression of functional bacterial undecaprenyl pyrophosphate synthase in the yeast rer2{Delta} mutant and CHO cells.

Authors:  Jeffrey S Rush; Sergey Matveev; Ziqiang Guan; Christian R H Raetz; C J Waechter
Journal:  Glycobiology       Date:  2010-08-04       Impact factor: 4.313

5.  Reducing the Level of Undecaprenyl Pyrophosphate Synthase Has Complex Effects on Susceptibility to Cell Wall Antibiotics.

Authors:  Yong Heon Lee; John D Helmann
Journal:  Antimicrob Agents Chemother       Date:  2013-06-24       Impact factor: 5.191

6.  Aberrant dolichol chain lengths as biomarkers for retinitis pigmentosa caused by impaired dolichol biosynthesis.

Authors:  Rong Wen; Byron L Lam; Ziqiang Guan
Journal:  J Lipid Res       Date:  2013-09-27       Impact factor: 5.922

7.  A missense mutation in DHDDS, encoding dehydrodolichyl diphosphate synthase, is associated with autosomal-recessive retinitis pigmentosa in Ashkenazi Jews.

Authors:  Lina Zelinger; Eyal Banin; Alexey Obolensky; Liliana Mizrahi-Meissonnier; Avigail Beryozkin; Dikla Bandah-Rozenfeld; Shahar Frenkel; Tamar Ben-Yosef; Saul Merin; Sharon B Schwartz; Artur V Cideciyan; Samuel G Jacobson; Dror Sharon
Journal:  Am J Hum Genet       Date:  2011-02-03       Impact factor: 11.025

8.  Whole-exome sequencing links a variant in DHDDS to retinitis pigmentosa.

Authors:  Stephan Züchner; Julia Dallman; Rong Wen; Gary Beecham; Adam Naj; Amjad Farooq; Martin A Kohli; Patrice L Whitehead; William Hulme; Ioanna Konidari; Yvonne J K Edwards; Guiqing Cai; Inga Peter; David Seo; Joseph D Buxbaum; Jonathan L Haines; Susan Blanton; Juan Young; Eduardo Alfonso; Jeffery M Vance; Byron L Lam; Margaret A Peričak-Vance
Journal:  Am J Hum Genet       Date:  2011-02-03       Impact factor: 11.025

9.  Undecaprenyl pyrophosphate involvement in susceptibility of Bacillus subtilis to rare earth elements.

Authors:  Takashi Inaoka; Kozo Ochi
Journal:  J Bacteriol       Date:  2012-08-17       Impact factor: 3.490

10.  Product chain-length determination mechanism of Z,E-farnesyl diphosphate synthase.

Authors:  Motoyoshi Noike; Takanori Ambo; Sayaka Kikuchi; Toshihide Suzuki; Satoshi Yamashita; Seiji Takahashi; Hirofumi Kurokawa; Sebabrata Mahapatra; Dean C Crick; Tanetoshi Koyama
Journal:  Biochem Biophys Res Commun       Date:  2008-09-13       Impact factor: 3.575
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