Literature DB >> 12591176

Alternative splicing: a novel mechanism to fine-tune the expression and function of the human AT1 receptor.

Terry S Elton1, Mickey M Martin.   

Abstract

Activation of the angiotensin II type 1 (AT(1)) receptor is closely involved in the pathogenesis of cardiovascular diseases; therefore, aberrant regulation of the production of this receptor might play a role in these disorders. Currently, there is strong evidence to suggest that the predominant mechanism regulating the number of AT(1) receptors is the modulation of mRNA stability. Here, we discuss the importance of alternative splicing as an additional post-transcriptional mechanism regulating human AT(1) receptor number and function.

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Year:  2003        PMID： 12591176     DOI： 10.1016/s1043-2760(02)00038-3

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  10 in total

Review 1.  Unravelling the Lesser Known Facets of Angiotensin II Type 1 Receptor.

Authors:  Mayank Chaudhary; Shashi Chaudhary
Journal:  Curr Hypertens Rep       Date:  2017-01       Impact factor: 5.369

Review 2.  International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected].

Authors:  Sadashiva S Karnik; Hamiyet Unal; Jacqueline R Kemp; Kalyan C Tirupula; Satoru Eguchi; Patrick M L Vanderheyden; Walter G Thomas
Journal:  Pharmacol Rev       Date:  2015-10       Impact factor: 25.468

Review 3.  Functional relevance of biased signaling at the angiotensin II type 1 receptor.

Authors:  Douglas G Tilley
Journal:  Endocr Metab Immune Disord Drug Targets       Date:  2011-06       Impact factor: 2.895

4.  A novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosis.

Authors:  Anupama Sahoo; Yun Min Jung; Ho-Keun Kwon; Hwa-Jung Yi; Suho Lee; Sunghoe Chang; Zee-Yong Park; Ki-Chul Hwang; Sin-Hyeog Im
Journal:  J Biol Chem       Date:  2008-08-15       Impact factor: 5.157

5.  HNF4alpha dysfunction as a molecular rational for cyclosporine induced hypertension.

Authors:  Monika Niehof; Jürgen Borlak
Journal:  PLoS One       Date:  2011-01-27       Impact factor: 3.240

6.  Functional changes in mRNA expression and alternative pre-mRNA splicing associated with the effects of nutrition on apoptosis and spermatogenesis in the adult testis.

Authors:  Yongjuan Guan; Guanxiang Liang; Graeme B Martin; Le Luo Guan
Journal:  BMC Genomics       Date:  2017-01-10       Impact factor: 3.969

Review 7.  Type 1 angiotensin receptor pharmacology: signaling beyond G proteins.

Authors:  Cristina Oro; Hongwei Qian; Walter G Thomas
Journal:  Pharmacol Ther       Date:  2006-10-14       Impact factor: 12.310

8.  Divergence of exonic splicing elements after gene duplication and the impact on gene structures.

Authors:  Zhenguo Zhang; Li Zhou; Ping Wang; Yang Liu; Xianfeng Chen; Landian Hu; Xiangyin Kong
Journal:  Genome Biol       Date:  2009-11-02       Impact factor: 13.583

9.  Splice-mediated Variants of Proteins (SpliVaP) - data and characterization of changes in signatures among protein isoforms due to alternative splicing.

Authors:  Matteo Floris; Massimiliano Orsini; Thangavel Alphonse Thanaraj
Journal:  BMC Genomics       Date:  2008-10-02       Impact factor: 3.969

10.  Identification of a Novel Transcript and Regulatory Mechanism for Microsomal Triglyceride Transfer Protein.

Authors:  Takashi Suzuki; Judy J Brown; Larry L Swift
Journal:  PLoS One       Date:  2016-01-15       Impact factor: 3.240
  10 in total

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