| Literature DB >> 12591148 |
Javier Sáez-Valero1, Lisa R Fodero, Anthony R White, Colin J Barrow, David H Small.
Abstract
The cellular origin of the acetylcholinesterase (AChE) associated with amyloid plaques in the Alzheimer's disease (AD) brain is unknown. In this study we report that amyloid beta-peptides (Abeta) increased AChE levels in both neuronal and astrocytic primary cultures, supporting the possibility that both neurons and glia may make a direct contribution to the pool of AChE seen around amyloid deposits in the AD brain.Entities:
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Year: 2003 PMID： 12591148 DOI： 10.1016/s0006-8993(02)04159-8
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252