Increased masking response to light after ablation of the visual cortex in mice.

Mice are known to suppress their wheel running when given a pulse of light in the night (masking response). The amount of suppression can be quantified; the response varies with the level of irradiance used during the light pulse. After ablation of the visual cortex, mice suppressed their activity more than sham-operated controls. In addition, the lesioned animals responded to lower levels of irradiance than controls. It is suggested that the visual cortex is not needed for the suppression of locomotor activity after a light pulse. Nevertheless it exerts an inhibitory influence on the masking response to light mediated by an irradiance detection system. When this inhibition is removed, even though pattern vision is lost, masking responses to ambient level of light are enhanced.