Literature DB >> 1259010

Effects of altering O2 delivery on VO2 of isolated, working muscle.

D H Horstman, M Gleser, J Delehunt.   

Abstract

Maximal oxygen consumption (VO2 max) and muscle blood flow (Q max) were measured in an isolated gracilis muscle preparation before and after alteration in perfusion pressure (BP), arterial oxygen saturation (SaO2), and hemoglobin concentration (Hb). Q varied directly with BP and inversely with Hb (viscosity) but was unaffected by changes in arterial SaO2. VO2 max varied directly with oxygen delivery under all conditions. These results indicate that VO2 max is normally limited by oxygen delivery rather than any intrinsic limiting of oxygen consumption of the muscle.

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Year:  1976        PMID: 1259010     DOI: 10.1152/ajplegacy.1976.230.2.327

Source DB:  PubMed          Journal:  Am J Physiol        ISSN: 0002-9513


  9 in total

Review 1.  Central and peripheral aspects of oxygen transport and adaptations with exercise.

Authors:  P D Wagner
Journal:  Sports Med       Date:  1991-03       Impact factor: 11.136

Review 2.  Regulation of increased blood flow (hyperemia) to muscles during exercise: a hierarchy of competing physiological needs.

Authors:  Michael J Joyner; Darren P Casey
Journal:  Physiol Rev       Date:  2015-04       Impact factor: 37.312

3.  Theoretical model of metabolic blood flow regulation: roles of ATP release by red blood cells and conducted responses.

Authors:  Julia C Arciero; Brian E Carlson; Timothy W Secomb
Journal:  Am J Physiol Heart Circ Physiol       Date:  2008-08-08       Impact factor: 4.733

4.  Local oxygen gradients near isolated mitochondria.

Authors:  A Clark; P A Clark
Journal:  Biophys J       Date:  1985-12       Impact factor: 4.033

5.  The effects of thermogenic agents on hindlimb oxygen consumption in the dog: ICI D7114 and noradrenaline.

Authors:  J L Gainer; M G Briscoe; B R Holloway
Journal:  Experientia       Date:  1993-01-15

6.  Regional blood flow distribution in dog during induced hypotension and low cardiac output. Spontaneous breathing versus artificial ventilation.

Authors:  N Viires; G Sillye; M Aubier; A Rassidakis; C Roussos
Journal:  J Clin Invest       Date:  1983-09       Impact factor: 14.808

7.  Oxygen uptake during swimming in a hypobaric hypoxic environment.

Authors:  F Ogita; I Tabata
Journal:  Eur J Appl Physiol Occup Physiol       Date:  1992

Review 8.  Limitations of oxygen transport to the cell.

Authors:  P D Wagner
Journal:  Intensive Care Med       Date:  1995-05       Impact factor: 17.440

9.  An investigation of arterial insufficiency in rat hindlimb. A combined 31P-n.m.r. and bloodflow study.

Authors:  R A Challiss; D J Hayes; R F Petty; G K Radda
Journal:  Biochem J       Date:  1986-06-01       Impact factor: 3.857

  9 in total

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