Literature DB >> 1258851

Identical twins discordant for ulcerative colitis with colon cancer.

W Bisordi, C J Lightdale.   

Abstract

A 22-year-old patient with a 16-year history of ulcerative colitis who developed multifocal anaplastic colon cancer is presented. His identical twin, proven by blood type, HL-A, and fingerprint analyses, has been completely asymptomatic. This report suggests that ulcerative colitis results from a polygenic predisposition without full penetrance. Subsequent development of colon cancer seems more likely related to the inflammatory disease that an independent genetic determinant.

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Year:  1976        PMID： 1258851     DOI： 10.1007/BF01074142

Source DB:  PubMed          Journal:  Am J Dig Dis        ISSN： 0002-9211


  21 in total

1.  FAMILIAL OCCURRENCE OF REGIONAL ENTERITIS AND ULCERATIVE COLITIS.

Authors:  P SHERLOCK; B M BELL; H STEINBERG; T P ALMY
Journal:  Gastroenterology       Date:  1963-09       Impact factor: 22.682

2.  FAMILIAL CANCER OF THE COLON.

Authors:  T KLUGE
Journal:  Acta Chir Scand       Date:  1964-04

3.  Chronic ulcerative colitis in twins; case report.

Authors:  C K LYONS; R W POSTLETHWAIT
Journal:  Gastroenterology       Date:  1948-03       Impact factor: 22.682

4.  Course and prognosis of ulcerative colitis: Part IV Carcinoma of the colon.

Authors: 
Journal:  Gut       Date:  1964-02       Impact factor: 23.059

5.  The occurrence of chronic ulcerative colitis in twin males.

Authors:  L R WEBB
Journal:  Gastroenterology       Date:  1950-07       Impact factor: 22.682

Review 6.  Hereditary benign and malignant lesions of the large bowel.

Authors:  J Wennstrom; E R Pierce; V A McKusick
Journal:  Cancer       Date:  1974-09       Impact factor: 6.860

7.  Differential diagnosis of the cancer family syndrome.

Authors:  H T Lynch; A J Krush
Journal:  Surg Gynecol Obstet       Date:  1973-02

8.  Discordance for ulcerative colitis in identical twins concordant for cholestatic liver disease. Report of 2 cases.

Authors:  J A Gregg; A H Baggenstoss
Journal:  Am J Dig Dis       Date:  1970-07

9.  Familial non-polypotic carcinoma of colon.

Authors:  J F Fielding
Journal:  Br Med J       Date:  1969-02-22

10.  Genetic aspects of ulcerative colitis and regional enteritis.

Authors:  T P Almy; P Sherlock
Journal:  Gastroenterology       Date:  1966-11       Impact factor: 22.682
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  1 in total

1.  Etiology of gastrointestinal cancer. Heredity vs environment.

Authors:  P Sherlock
Journal:  Am J Dig Dis       Date:  1976-01
  1 in total

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