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Literature DB >> 12586468

Characterization and role of protozoan parasite proteasomes.

André Paugam¹, Anne Laure Bulteau, Jean Dupouy-Camet, Claudine Creuzet, Bertrand Friguet.

Abstract

The proteasome, a large non-lysosomal multi-subunit protease complex, is ubiquitous in eukaryotic cells. In protozoan parasites, the proteasome is involved in cell differentiation and replication, and could therefore be a promising therapeutic target. This article reviews the present knowledge of proteasomes in protozoan parasites of medical importance such as Giardia, Entamoeba, Leishmania, Trypanosoma, Plasmodium and Toxoplasma spp.

Entities: Disease

Mesh：

Substances：

Year: 2003 PMID： 12586468 DOI： 10.1016/s1471-4922(02)00064-8

Source DB: PubMed Journal: Trends Parasitol ISSN： 1471-4922

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Cited

23 in total

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Authors: Catherine Z Chen; Liudmila Kulakova; Noel Southall; Juan J Marugan; Andrey Galkin; Christopher P Austin; Osnat Herzberg; Wei Zheng
Journal: Antimicrob Agents Chemother Date: 2010-11-15 Impact factor: 5.191

2. Investigation on the 19S ATPase proteasome subunits (Rpt1-6) conservation and their differential gene expression in Schistosoma mansoni.

Authors: Olavo S Pereira-Júnior; Roberta Verciano Pereira; Camila S Silva; William Castro-Borges; Renata Guerra Sá; Fernanda J Cabral; Sérgio H Silva; Cláudia S Soares; Enyara R Morais; Erika B C Moreira; Lizandra G Magalhães; Fabiana M de Paula; Vanderlei Rodrigues
Journal: Parasitol Res Date: 2012-09-28 Impact factor: 2.289

3. Knockdown of LdMC1 and Hsp70 by antisense oligonucleotides causes cell-cycle defects and programmed cell death in Leishmania donovani.

Authors: Puneet Raina; Sukhbir Kaur
Journal: Mol Cell Biochem Date: 2011-07-31 Impact factor: 3.396

4. Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast.

Authors: Makoah N Aminake; Sebastian Schoof; Ludmilla Sologub; Monika Leubner; Marc Kirschner; Hans-Dieter Arndt; Gabriele Pradel
Journal: Antimicrob Agents Chemother Date: 2011-01-18 Impact factor: 5.191

5. The Giardia cell cycle progresses independently of the anaphase-promoting complex.

Authors: Stéphane Gourguechon; Liam J Holt; W Zacheus Cande
Journal: J Cell Sci Date: 2013-03-22 Impact factor: 5.285

6. The ubiquitin-proteasome system in Strongyloididae. Biochemical evidence for developmentally regulated proteolysis in Strongyloides venezuelensis.

Authors: Fabiana M de Paula; William Castro-Borges; Olavo S Pereira Júnior; Matheus de Souza Gomes; Marlene T Ueta; Vanderlei Rodrigues
Journal: Parasitol Res Date: 2009-04-08 Impact factor: 2.289

Characterization and role of protozoan parasite proteasomes.

1. High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements.

2. Investigation on the 19S ATPase proteasome subunits (Rpt1-6) conservation and their differential gene expression in Schistosoma mansoni.

3. Knockdown of LdMC1 and Hsp70 by antisense oligonucleotides causes cell-cycle defects and programmed cell death in Leishmania donovani.

4. Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast.

5. The Giardia cell cycle progresses independently of the anaphase-promoting complex.

6. The ubiquitin-proteasome system in Strongyloididae. Biochemical evidence for developmentally regulated proteolysis in Strongyloides venezuelensis.

Review 7. The global cysteine peptidase landscape in parasites.

8. The Ubiquitin Proteome of Toxoplasma gondii Reveals Roles for Protein Ubiquitination in Cell-Cycle Transitions.

9. Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes.

10. Toxoplasma gondii Proteasome Subunit Alpha Type 1 with Chitosan: A Promising Alternative to Traditional Adjuvant.