| Literature DB >> 12586435 |
Melanie Ziman1, Jennifer Rodger, Sherralee Lukehurst, Davina Hancock, Sarah Dunlop, Lyn Beazley.
Abstract
Expression of the transcription factor Pax6 was assessed immunohistochemically in embryonic chick retina during retino-tectal map formation. A low dorsal to high ventral gradient was found that correlated with expression of the axonal guidance cue EphB2. Furthermore, transfection of Pax6 into undifferentiated P19 cells up-regulated EphB2. The results raise the possibility that Pax6 is upstream of EphB2 and that its graded expression defines the dorso-ventral axis of the retino-tectal projection.Entities:
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Year: 2003 PMID： 12586435 DOI： 10.1016/s0165-3806(02)00605-3
Source DB: PubMed Journal: Brain Res Dev Brain Res ISSN： 0165-3806