Literature DB >> 12585925

First total synthesis of leucamide A.

Wenlong Wang1, Fajun Nan.   

Abstract

The first total synthesis of marine bioactive cyclic heptapeptide Leucamide A has been accomplished, including a simple method for construction of the 4,2-bisheterocycle tandem pair substructure that employs a DAST-mediated cyclization of beta-hydroxy amide and final HBTU-promoted ring closing.

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Year:  2003        PMID： 12585925     DOI： 10.1021/jo026799+

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

1.  Cytotoxic 1,3-Thiazole and 1,2,4-Thiadiazole Alkaloids from Penicillium oxalicum: Structural Elucidation and Total Synthesis.

Authors:  Zheng Yang; Nianyu Huang; Bang Xu; Wenfeng Huang; Tianpeng Xie; Fan Cheng; Kun Zou
Journal:  Molecules       Date:  2016-02-26       Impact factor: 4.411

2.  Synthesis and antiviral activity of conformational analogues of leucamide A.

Authors:  Wen-Long Wang; Hai-Jun Chen; Wei-Ping Ma; Min Gu; Min-Zhi Fan; Jing-Ya Li; Bainian Feng; Fa-Jun Nan
Journal:  Molecules       Date:  2012-12-07       Impact factor: 4.411

Review 3.  An Overview of Bioactive 1,3-Oxazole-Containing Alkaloids from Marine Organisms.

Authors:  Jinyun Chen; Sunyan Lv; Jia Liu; Yanlei Yu; Hong Wang; Huawei Zhang
Journal:  Pharmaceuticals (Basel)       Date:  2021-12-06
  3 in total

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