Literature DB >> 12585423

Rapid reduction of pentavalent antimony by trypanothione: potential relevance to antimonial activation.

Siucheong Yan1, Iris L K Wong, Larry M C Chow, Hongzhe Sun.   

Abstract

The dithiol trypanothione can reduce an antiparasitic pentavalent antimony agent to trivalent rapidly; this reduction process is both pH and temperature dependent and trypanothione may therefore play an important role in the activation of the drug.

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Year:  2003        PMID： 12585423     DOI： 10.1039/b210240d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

Review 1.  Drug resistance in leishmaniasis.

Authors:  Simon L Croft; Shyam Sundar; Alan H Fairlamb
Journal:  Clin Microbiol Rev       Date:  2006-01       Impact factor: 26.132

Review 2.  Availability, Toxicology and Medical Significance of Antimony.

Authors:  Argyrios Periferakis; Ana Caruntu; Aristodemos-Theodoros Periferakis; Andreea-Elena Scheau; Ioana Anca Badarau; Constantin Caruntu; Cristian Scheau
Journal:  Int J Environ Res Public Health       Date:  2022-04-12       Impact factor: 4.614

3.  Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background.

Authors:  Saskia Decuypere; Manu Vanaerschot; Kirstyn Brunker; Hideo Imamura; Sylke Müller; Basudha Khanal; Suman Rijal; Jean-Claude Dujardin; Graham H Coombs
Journal:  PLoS Negl Trop Dis       Date:  2012-02-28

4.  The elements of life and medicines.

Authors:  Prinessa Chellan; Peter J Sadler
Journal:  Philos Trans A Math Phys Eng Sci       Date:  2015-03-13       Impact factor: 4.226

5.  Sb(V) reactivity with human blood components: redox effects.

Authors:  Silvana López; Luis Aguilar; Luis Mercado; Manuel Bravo; Waldo Quiroz
Journal:  PLoS One       Date:  2015-01-23       Impact factor: 3.240

6.  Trypanothione Reductase Gene Mutations in Meglumine Antimoniate Resistant Isolates from Cutaneous Leishmaniasis Patients Using Molecular Dynamics Method.

Authors:  Fatemeh Fozongari; Abdolhossein Dalimi; Seid Shahriar Arab; Mehrdad Behmanesh; Anahita Khammari
Journal:  Iran J Parasitol       Date:  2020 Oct-Dec       Impact factor: 1.012

7.  Role of efflux pumps and intracellular thiols in natural antimony resistant isolates of Leishmania donovani.

Authors:  Smita Rai; Sudhir K Goel; Upendra Nath Dwivedi; Shyam Sundar; Neena Goyal
Journal:  PLoS One       Date:  2013-09-17       Impact factor: 3.240
  7 in total

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